{"id":"W4281295871","doi":"10.1161/circulationaha.122.060402","title":"Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Diet and metabolism studies","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Medicine; Ejection fraction; Dapagliflozin; Heart failure; Metabolomics; Cardiology; Internal medicine; Pharmacology; Bioinformatics; Endocrinology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001854885,0.00006747469,0.0002363808,0.0001057808,0.00007317308,0.000001870652,0.00003018331,0.0000258558,0.0000138702],"category_scores_gemma":[0.0001240373,0.00004919278,0.00005893713,0.0004661877,0.00003178194,0.00005630482,0.00002640566,0.0001438034,6.72546e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005163735,"about_ca_system_score_gemma":0.00006138519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004035667,"about_ca_topic_score_gemma":0.0000119842,"domain_scores_codex":[0.9992874,0.00008584817,0.0001869286,0.0001257322,0.0002328228,0.00008121412],"domain_scores_gemma":[0.9995767,0.0000496929,0.0001352954,0.000160537,0.00006454958,0.00001324986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001137426,0.00008150616,0.4562323,0.0001664071,0.00004186008,4.882999e-7,0.0002802373,0.0005542987,0.5418293,0.0002810551,0.00009655731,0.0003222847],"study_design_scores_gemma":[0.0009861436,0.00006342281,0.9295537,0.00006449663,0.0001513369,0.000005997992,0.0005445164,0.0001242327,0.06778016,0.00007862705,0.0006017671,0.00004556205],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978967,0.0005496255,0.00005179745,0.0003085152,0.0003405564,0.0005503439,0.000001453136,0.00001372555,0.0002872935],"genre_scores_gemma":[0.9993632,0.000008891453,0.0004335223,0.00003682106,0.00005327892,0.0000661939,0.000009390708,0.00000943942,0.00001921599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4740491,"threshold_uncertainty_score":0.2006023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134262425410394,"score_gpt":0.2457449206362781,"score_spread":0.2344022963821741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}