{"id":"W4281297090","doi":"10.1098/rsta.2020.0423","title":"Protometabolism as out-of-equilibrium chemistry","year":2022,"lang":"en","type":"review","venue":"Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Simons Foundation","keywords":"Extant taxon; Abiogenesis; Biochemical engineering; Earth science; Hydrothermal vent; Autocatalytic reaction; Lead (geology); Chemistry; Astrobiology; Computer science; Hydrothermal circulation; Paleontology; Geology; Biology; Evolutionary biology; Physics; Statistical physics; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212341,0.0002848955,0.0009700981,0.00002001706,0.0001925537,0.00002615737,0.0005148297,0.00007862135,0.0005444515],"category_scores_gemma":[0.0000190846,0.0001794487,0.001280234,0.0004019615,0.000589337,0.00006540885,0.00008827982,0.000571216,0.000004147183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001778682,"about_ca_system_score_gemma":0.0001066309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007024556,"about_ca_topic_score_gemma":3.720416e-9,"domain_scores_codex":[0.9985143,0.00003176734,0.0004386725,0.0003007995,0.0004699407,0.0002445082],"domain_scores_gemma":[0.9991084,0.0003341684,0.0001833625,0.0002443648,0.00001883752,0.0001108373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001798161,0.006014755,0.000009048399,0.09873127,0.003233079,0.000001070454,0.002554474,0.01962189,0.0001955682,0.6457732,0.0002071924,0.2236405],"study_design_scores_gemma":[0.0006126086,0.0002986239,0.000004610822,0.006344901,0.002969404,0.000007969546,0.0002443942,0.08396437,0.000275657,0.4161692,0.4874378,0.001670477],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.006635351,0.9002756,0.04891713,0.003422125,0.002237054,0.00596241,0.002011973,0.0004438264,0.03009448],"genre_scores_gemma":[0.6127566,0.36164,0.01144473,0.00008705764,0.007205962,0.003057681,0.00005884589,0.0004519145,0.003297199],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.6061213,"threshold_uncertainty_score":0.7317707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03725746953274147,"score_gpt":0.2948806218006497,"score_spread":0.2576231522679083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}