{"id":"W4281298216","doi":"10.1371/journal.ppat.1010511","title":"VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Calgary","keywords":"Bacterial adhesin; Borrelia burgdorferi; Biology; Lyme disease; Antigenic variation; Microbiology; Pathogen; Cell biology; Antigen; Immunology; Genetics; Gene; Antibody; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074783,0.0001836197,0.0001355738,0.0001505574,0.0001076313,0.000264776,0.00008809803,0.0001569508,0.0005856153],"category_scores_gemma":[0.0000867511,0.00005487038,0.0001062954,0.00009943403,0.0001493802,0.0001495943,0.0002234144,0.0002342225,0.0001809213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620764,"about_ca_system_score_gemma":0.00009968134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000447185,"about_ca_topic_score_gemma":0.0005592518,"domain_scores_codex":[0.9999355,0.00001340605,0.000004169664,0.00001242289,0.00001809802,0.00001637452],"domain_scores_gemma":[0.9999286,0.000008173713,0.00002424479,0.000006192012,0.000011632,0.00002110908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002014336,0.000006936158,0.0006010126,0.00001218032,0.000001762799,0.00004979591,0.000008555086,0.00002261689,0.9979858,0.0001469087,0.00001788181,0.00112632],"study_design_scores_gemma":[0.000009941539,0.000299452,0.02431035,0.000008811832,0.000009342285,0.0008947825,0.00008124761,0.001387351,0.9668567,0.0001654137,0.005970638,0.000006061229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921108,0.00189994,0.004600564,0.00008237617,0.00001382391,0.0000112945,0.00009171726,0.00005220597,0.001137241],"genre_scores_gemma":[0.9955992,0.0006024081,0.001748301,0.0000315434,0.000005290686,0.000008596046,0.0001398741,0.000005776685,0.001858979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005856153,"threshold_uncertainty_score":0.001959085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011480005673203,"score_gpt":0.2245300643716419,"score_spread":0.2130500586984389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}