{"id":"W4281298216","doi":"10.1371/journal.ppat.1010511","title":"VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Calgary","keywords":"Bacterial adhesin; Borrelia burgdorferi; Biology; Lyme disease; Antigenic variation; Microbiology; Pathogen; Cell biology; Antigen; Immunology; Genetics; Gene; Antibody; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000310845,0.0002161859,0.000232462,0.0000520578,0.0009270231,0.00003170781,0.00057593,0.00009426881,0.0004147893],"category_scores_gemma":[0.0002194098,0.0001220326,0.0003809522,0.0002621094,0.0001320931,0.00004872452,0.0003646964,0.0002377286,0.0000445007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009656791,"about_ca_system_score_gemma":0.000171525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006771442,"about_ca_topic_score_gemma":0.00004192393,"domain_scores_codex":[0.9983142,0.0005273034,0.0002957536,0.0003537266,0.0001296053,0.000379431],"domain_scores_gemma":[0.9985677,0.0003251825,0.0001896373,0.0007523261,0.000120856,0.00004432313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004484584,0.0004232007,0.01013319,0.00003001857,0.0008350206,0.000001357948,0.001757803,0.0009707513,0.9832336,0.0005753002,0.001501487,0.00008986699],"study_design_scores_gemma":[0.001346996,0.0003699931,0.9586306,0.00002059143,0.000989988,0.00001205795,0.000405606,0.00004387603,0.02670048,0.0003700293,0.01082117,0.0002886269],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907973,0.001639009,0.0001666526,0.002136469,0.001593533,0.001718702,0.001873299,0.00005069603,0.00002436765],"genre_scores_gemma":[0.9976676,0.00001433248,0.00001349099,0.0009575398,0.0001903882,0.0005429177,0.000208202,0.0000370732,0.0003684568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9565331,"threshold_uncertainty_score":0.7130006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011480005673203,"score_gpt":0.2245300643716419,"score_spread":0.2130500586984389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}