{"id":"W4281382780","doi":"10.1101/2022.05.12.22275021","title":"The Proportion of Randomized Controlled Trials That Inform Clinical Practice: A Longitudinal Cohort Study of Trials Registered on ClinicalTrials.gov","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Meta-analysis and systematic reviews","field":"Decision Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Clinical trial; Medicine; Randomized controlled trial; Clinical research; Clinical Practice; Disease; Family medicine; Clinical study design; Alternative medicine; Cohort; Physical therapy; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.5287497,0.0008731193,0.002516013,0.006635315,0.002406944,0.006245658,0.003837188,0.004144533,0.004045813],"category_scores_gemma":[0.7379861,0.001679668,0.005815875,0.008784953,0.005174241,0.008502869,0.005035423,0.004438242,0.0006689089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002668215,"about_ca_system_score_gemma":0.005578577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002858959,"about_ca_topic_score_gemma":0.001995775,"domain_scores_codex":[0.3112245,0.5373554,0.07882173,0.03101867,0.03748498,0.004094765],"domain_scores_gemma":[0.09520737,0.6248574,0.1820895,0.07927898,0.01570755,0.002859246],"domain_codex":"methods","domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00948037,0.0005115207,0.9430825,0.001810328,0.01291765,0.0002361382,0.003033819,0.001525556,0.0002826198,0.004306387,0.002253865,0.02055927],"study_design_scores_gemma":[0.005212186,0.005779338,0.9097301,0.003855889,0.01712642,0.001908309,0.002932121,0.01997375,0.001423927,0.01618065,0.01536588,0.000511348],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8914796,0.01583067,0.05995055,0.006159737,0.0004213794,0.008917107,0.01228075,0.0003059428,0.004654281],"genre_scores_gemma":[0.9800524,0.0006567437,0.01111275,0.001097625,0.0001208737,0.004592744,0.002005261,0.00005976285,0.0003018261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4712503,"threshold_uncertainty_score":0.5811355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.901799275060594,"score_gpt":0.6640880843483667,"score_spread":0.2377111907122272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}