{"id":"W4281384988","doi":"10.1016/j.celrep.2022.110847","title":"Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Canada Foundation for Innovation; Research Nova Scotia; Beatrice Hunter Cancer Research Institute; Nova Scotia Research Innovation Trust; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Arginase; Lymphocyte; Biology; Mitochondrion; Cell biology; Immunology; Genetics; Arginine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004502467,0.0002761038,0.0003630223,0.0001522085,0.0004883367,0.00002920624,0.0002772759,0.0002200184,0.005540316],"category_scores_gemma":[0.00006222112,0.0003071147,0.000221699,0.0002021734,0.00009420655,0.00008416716,0.0003863682,0.00048722,0.0001418101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000767666,"about_ca_system_score_gemma":0.0002747499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002973874,"about_ca_topic_score_gemma":0.00001059373,"domain_scores_codex":[0.9975458,0.0004468385,0.0006851608,0.0006094491,0.0001822343,0.0005305104],"domain_scores_gemma":[0.9982908,0.00006694757,0.0006366867,0.0008845645,0.00009446972,0.0000265003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001798271,0.0003229677,0.001764221,0.00001560523,0.0001727095,0.001368066,0.0004128045,0.001194467,0.9852586,0.00001417729,0.008578534,0.000718057],"study_design_scores_gemma":[0.002794274,0.0001737973,0.002668478,0.00001685591,0.0001276178,0.0006473946,0.000247223,0.00001680604,0.9017415,0.0001488266,0.09093445,0.0004827707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772513,0.004272935,0.0001542151,0.00007858215,0.01372903,0.0005415917,0.00003988797,0.0001741098,0.003758369],"genre_scores_gemma":[0.9550224,0.00004127292,0.00001768866,0.0001714828,0.00004468359,0.0001833193,0.0009497232,0.0000647142,0.04350471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08351706,"threshold_uncertainty_score":0.9999381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005769381151732484,"score_gpt":0.2068747369993423,"score_spread":0.2011053558476098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}