{"id":"W4281386314","doi":"10.1212/wnl.0000000000200544","title":"Association of <i>APOE</i> -Independent Alzheimer Disease Polygenic Risk Score With Brain Amyloid Deposition in Asymptomatic Older Adults","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Fondation pour la Recherche sur Alzheimer; IXICO; H. Lundbeck A/S; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Eisai; Sorbonne Université; Servier; Institut National de la Santé et de la Recherche Médicale; Merz Pharmaceuticals; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Agence Nationale de la Recherche; University of Southern California; Pfizer; BioClinica; Biogen; Assistance publique-Hôpitaux de Paris; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Alzheimer's Disease Neuroimaging Initiative; Asymptomatic; Medicine; Cohort; Internal medicine; Pittsburgh compound B; Amyloid (mycology); Alzheimer's disease; Odds ratio; Disease; Risk factor; Oncology; Psychology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001061253,0.0004188244,0.000314444,0.0006201805,0.0003295584,0.0004005299,0.0002736481,0.0004493013,0.001030282],"category_scores_gemma":[0.0021636,0.0001682432,0.0005102513,0.0005847243,0.0002284313,0.000244709,0.0003868819,0.0002921266,0.0001065333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001572523,"about_ca_system_score_gemma":0.0001794027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005234926,"about_ca_topic_score_gemma":0.005441773,"domain_scores_codex":[0.9995797,0.0001374172,0.0000718403,0.0001146871,0.00005252731,0.00004371965],"domain_scores_gemma":[0.9988605,0.0002739304,0.0004787744,0.0001466522,0.0001013929,0.0001386532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003161177,0.0000287783,0.9981363,0.000004827036,0.0001125333,0.00004851906,0.00002241047,0.0000751432,0.0003518544,0.000012961,0.00004534142,0.0008452014],"study_design_scores_gemma":[0.00001392672,0.0001172327,0.9991502,0.000001401641,0.00004193294,0.000154232,0.00002237516,0.0003726998,0.0000570002,0.00002543194,0.00004112706,0.000002473106],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996001,0.0000382527,0.00008633574,0.000009047834,0.000001705411,0.000005905285,0.0001641737,0.000002338937,0.00009222711],"genre_scores_gemma":[0.9994915,0.00001454289,0.0001341309,0.000008073723,0.000004694591,0.000005845009,0.0002976171,9.146611e-7,0.00004266436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005234926,"threshold_uncertainty_score":0.01040894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006504909767829148,"score_gpt":0.2502727033474366,"score_spread":0.2437677935796075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}