{"id":"W4281386803","doi":"10.1016/j.nbd.2022.105775","title":"Autoimmunity to a ribonucleoprotein drives neuron loss in multiple sclerosis models","year":2022,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cameco (Canada); University of Saskatchewan","funders":"","keywords":"Neurodegeneration; Heterogeneous nuclear ribonucleoprotein; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Ribonucleoprotein; Autoimmunity; Stress granule; Biology; Amyotrophic lateral sclerosis; Neuroscience; Immunology; Cell biology; Medicine; Antibody; RNA; Disease; Pathology; Messenger RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000251607,0.000981285,0.0007700484,0.0007599403,0.0004029252,0.0004011092,0.0004810321,0.0007517883,0.001201843],"category_scores_gemma":[0.00008061617,0.0003120519,0.000545734,0.0003954696,0.0004787687,0.0002987552,0.0003173088,0.00178809,0.0006431426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004868762,"about_ca_system_score_gemma":0.0003341346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007076699,"about_ca_topic_score_gemma":0.00164746,"domain_scores_codex":[0.9994572,0.00007989565,0.00007466977,0.0001517465,0.0001412693,0.00009515227],"domain_scores_gemma":[0.9998289,0.00001559276,0.00005105238,0.00002282248,0.00001867576,0.00006294485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002380038,0.0002197914,0.0001079534,0.00006821975,0.00001145497,0.00008483553,0.00002917186,0.00005683688,0.9984103,0.00004954211,0.00004861057,0.0006751591],"study_design_scores_gemma":[0.00007518957,0.003752975,0.003552443,0.00002418968,0.00006649666,0.0004735262,0.00004020235,0.0009510252,0.9880356,0.0001011838,0.002915276,0.00001193784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871224,0.003338151,0.004819069,0.000192856,0.0001544476,0.0002908444,0.0008616799,0.0003259301,0.002894588],"genre_scores_gemma":[0.9757391,0.004469197,0.007953086,0.0002237702,0.00007308873,0.0007357412,0.001438747,0.00006360345,0.009303723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201843,"threshold_uncertainty_score":0.004020572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06409957416909683,"score_gpt":0.2835688450641902,"score_spread":0.2194692708950933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}