{"id":"W4281386954","doi":"10.1097/ccm.0000000000005589","title":"Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19*","year":2022,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Blackberry (Canada); Queen's University; BC Children's Hospital; Université de Sherbrooke; University of Toronto; Kingston General Hospital; Mount Sinai Hospital; University of Calgary; Vancouver General Hospital; Health Sciences Centre; Ottawa Hospital; McGill University; McGill University Health Centre; University of Ottawa; Sunnybrook Health Science Centre; BC Centre for Disease Control; St. Michael's Hospital; Centre for Advancing Health Outcomes; St. Paul's Hospital; University of Victoria; Surrey Memorial Hospital; University of British Columbia","funders":"Grifols; Merck Canada; University of British Columbia; Queen's University; Genome British Columbia; McGill University; University of Ottawa; Public Health Agency of Canada; St. Paul's Foundation; Genome Canada; University of Victoria; Moderna; CSL Behring; Fonds de Recherche du Québec - Santé; Michael Smith Health Research BC; Public Health Agency; GlaxoSmithKline; Canadian Institutes of Health Research; Jeffrey Modell Foundation","keywords":"Medicine; Coronavirus disease 2019 (COVID-19); Renin–angiotensin system; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Peptidyl-Dipeptidase A; Pharmacology; Intensive care medicine; Internal medicine; Virology; Disease; Infectious disease (medical specialty); Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836175,0.0001925768,0.0002987882,0.0003027664,0.0002744793,0.0003595729,0.0001283159,0.0001941408,0.001698388],"category_scores_gemma":[0.0008136736,0.0001303499,0.0003787121,0.0003353399,0.0001541927,0.0001447464,0.0001714137,0.0003868166,0.0001384529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002505388,"about_ca_system_score_gemma":0.000376968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00631108,"about_ca_topic_score_gemma":0.01063414,"domain_scores_codex":[0.9998248,0.00002309449,0.00001402091,0.0000387427,0.00003880119,0.00006047085],"domain_scores_gemma":[0.9994435,0.00005974549,0.0003002039,0.00002956711,0.00004793104,0.0001191252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001334438,0.00001469695,0.9983267,0.000005541597,0.00002604057,0.0000456527,0.00001466347,0.00001060586,0.0002390657,0.000007302049,0.00006763362,0.001108656],"study_design_scores_gemma":[0.000006901859,0.00007060026,0.9994668,0.000003733471,0.00001983326,0.0001887781,0.00005538646,0.00004730168,0.00004997131,0.000007113957,0.00008226377,0.00000130386],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989476,0.0003182551,0.00003721576,0.00005482797,0.0000090004,0.000003865251,0.0002851985,0.000002679184,0.0003414406],"genre_scores_gemma":[0.9993963,0.0001184134,0.00003958813,0.00003817446,0.00001802458,0.000003383461,0.000255565,0.000001231908,0.0001294224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00631108,"threshold_uncertainty_score":0.01254869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06182532378828312,"score_gpt":0.4136479231224738,"score_spread":0.3518225993341907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}