{"id":"W4281388536","doi":"10.1053/j.gastro.2022.05.029","title":"Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn’s Disease","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"U.S. Army Medical Research Acquisition Activity; Janssen Pharmaceuticals; Janssen Research and Development; National Cancer Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Takeda Canada; Canadian Institutes of Health Research; U.S. Navy; Genentech; Fundação para a Ciência e a Tecnologia; Ferring Pharmaceuticals; National Institutes of Health; Canada Research Chairs; Government of South Australia; Crohn's and Colitis Foundation; Leona M. and Harry B. Helmsley Charitable Trust; Naval Medical Research Center; Sanford J. Grossman Charitable Trust; U.S. Department of Defense; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Shire; Bristol-Myers Squibb; Crohn's and Colitis Foundation of America; University of Toronto; Kenneth Rainin Foundation; AbbVie Canada; Boehringer Ingelheim","keywords":"Granulocyte macrophage colony-stimulating factor; Medicine; Granulocyte; Granulocyte macrophage colony-stimulating factor receptor; Immunology; Macrophage; Colony-stimulating factor; Autoantibody; Macrophage colony-stimulating factor; Antibody; Biology; Cytokine; Haematopoiesis; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002154647,0.0005388967,0.0004940814,0.0002455199,0.0008765587,0.00008946429,0.0003937315,0.0001710093,0.0004536023],"category_scores_gemma":[0.0002033294,0.0006139619,0.000288067,0.0001468746,0.0002951619,0.00003616375,0.0004201911,0.0004983382,0.00001741324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009919869,"about_ca_system_score_gemma":0.0001193007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005984245,"about_ca_topic_score_gemma":0.0001658669,"domain_scores_codex":[0.9962984,0.0005535329,0.0007176484,0.001090164,0.0004196556,0.0009205553],"domain_scores_gemma":[0.9983757,0.000110919,0.0003526351,0.0005386334,0.0001793787,0.0004427157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003177004,0.0002624209,0.9584268,0.00008781034,0.0002256165,0.0005293893,0.0003433391,0.0140824,0.02149248,0.00001623764,0.0001850967,0.001171421],"study_design_scores_gemma":[0.002931325,0.001022159,0.9879634,0.00003358647,0.0001276079,0.00003824549,0.00004636044,0.006842844,0.0002471211,0.00003688751,0.0003730283,0.0003374246],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99139,0.0001524594,0.0003187982,0.0004977929,0.0003973571,0.001327593,0.00576292,0.0001343316,0.00001875487],"genre_scores_gemma":[0.9953029,0.00002932292,0.0006595423,0.001019239,0.000200905,0.0004448822,0.002154751,0.0001091072,0.00007940405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02953662,"threshold_uncertainty_score":0.9996312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315257751641745,"score_gpt":0.253761421088611,"score_spread":0.2406088435721936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}