{"id":"W4281388536","doi":"10.1053/j.gastro.2022.05.029","title":"Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn’s Disease","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"U.S. Army Medical Research Acquisition Activity; Janssen Pharmaceuticals; Janssen Research and Development; National Cancer Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Takeda Canada; Canadian Institutes of Health Research; U.S. Navy; Genentech; Fundação para a Ciência e a Tecnologia; Ferring Pharmaceuticals; National Institutes of Health; Canada Research Chairs; Government of South Australia; Crohn's and Colitis Foundation; Leona M. and Harry B. Helmsley Charitable Trust; Naval Medical Research Center; Sanford J. Grossman Charitable Trust; U.S. Department of Defense; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Shire; Bristol-Myers Squibb; Crohn's and Colitis Foundation of America; University of Toronto; Kenneth Rainin Foundation; AbbVie Canada; Boehringer Ingelheim","keywords":"Granulocyte macrophage colony-stimulating factor; Medicine; Granulocyte; Granulocyte macrophage colony-stimulating factor receptor; Immunology; Macrophage; Colony-stimulating factor; Autoantibody; Macrophage colony-stimulating factor; Antibody; Biology; Cytokine; Haematopoiesis; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004499166,0.0004665451,0.0004024359,0.001010508,0.0004769185,0.0008341625,0.0002864575,0.001024736,0.001222071],"category_scores_gemma":[0.00311778,0.0002925564,0.000334306,0.0005231198,0.00040817,0.0005600853,0.0002810208,0.0009976469,0.0003752279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003427839,"about_ca_system_score_gemma":0.0002646902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001682876,"about_ca_topic_score_gemma":0.001876485,"domain_scores_codex":[0.9995401,0.000118532,0.00004080114,0.00006825559,0.00006787895,0.0001645329],"domain_scores_gemma":[0.997227,0.0009052519,0.0006796648,0.0001335054,0.0002521929,0.0008024497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004243637,0.00008118014,0.9935594,0.000006917186,0.00002997745,0.000854125,0.00007165475,0.00006088467,0.002589786,0.00004240577,0.0001910773,0.002088234],"study_design_scores_gemma":[0.000009367711,0.0002220941,0.995516,0.000009082986,0.0000302861,0.002431865,0.0001177514,0.0003044753,0.0007782254,0.00006992462,0.0005041361,0.000006825282],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981823,0.0004537656,0.00009443075,0.0001261939,0.00005055902,0.000002541595,0.00006102364,0.000007677359,0.001021544],"genre_scores_gemma":[0.9994431,0.00009527297,0.00005210645,0.0000670021,0.00003790629,0.00000166972,0.00008533668,0.000002869787,0.0002147366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001682876,"threshold_uncertainty_score":0.004088223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315257751641745,"score_gpt":0.253761421088611,"score_spread":0.2406088435721936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}