{"id":"W4281390999","doi":"10.1016/j.lungcan.2022.05.012","title":"Efficacy and safety of lorlatinib in Asian and non-Asian patients with ALK-positive advanced non-small cell lung cancer: Subgroup analysis of a global phase 2 trial","year":2022,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Crizotinib; Lung cancer; Hazard ratio; Confidence interval; Clinical endpoint; Oncology; Population; ALK inhibitor; Adverse effect; Cancer; Gastroenterology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003105208,0.001541723,0.003562155,0.0005500813,0.0003276677,0.001487609,0.0005854716,0.0009295236,0.001389005],"category_scores_gemma":[0.002131287,0.0004096256,0.0083706,0.0008643307,0.0007091921,0.001212927,0.000709403,0.002043128,0.0002552333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008206344,"about_ca_system_score_gemma":0.0008059934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008946519,"about_ca_topic_score_gemma":0.003626198,"domain_scores_codex":[0.9988692,0.0005068943,0.0001327501,0.0002216751,0.00009696302,0.0001724864],"domain_scores_gemma":[0.9989611,0.0003739318,0.0002707653,0.0001526692,0.00007436316,0.0001671659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7779031,0.001138333,0.08910194,0.002129122,0.07288786,0.0002732117,0.0002918362,0.003041589,0.007104322,0.000232981,0.002455526,0.04344022],"study_design_scores_gemma":[0.4072146,0.06100317,0.3579592,0.0004874084,0.152638,0.001075192,0.00103249,0.006127495,0.003574027,0.002416366,0.006154423,0.0003177555],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888648,0.008286543,0.0002846929,0.0004189723,0.0001112668,0.0002234442,0.000969808,0.00002724959,0.0008132603],"genre_scores_gemma":[0.995739,0.001434648,0.0002064106,0.0004594415,0.0001135721,0.0002148309,0.001362153,0.00001884443,0.0004512311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003562155,"threshold_uncertainty_score":0.01642209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0043017809103495,"score_gpt":0.3100869242154153,"score_spread":0.3057851433050658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}