{"id":"W4281394659","doi":"10.1093/noajnl/vdac076","title":"Detection of temozolomide-induced hypermutation and response to PD-1 checkpoint inhibitor in recurrent glioblastoma","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; McGill University Health Centre","funders":"National Cancer Institute; Cancer Research Society; AbbVie","keywords":"Somatic hypermutation; Temozolomide; Immune system; Immunotherapy; Cancer research; Biology; Immunology; Glioma; Antibody; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003141298,0.0001176171,0.0003034716,0.0003576749,0.0000865781,0.000003233105,0.0000403931,0.00004720702,0.00002227129],"category_scores_gemma":[0.0005132105,0.0001009116,0.00004331855,0.0003912009,0.00003808709,0.00007088879,0.00007947041,0.0001930328,0.000004576213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064014,"about_ca_system_score_gemma":0.00009955344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001647939,"about_ca_topic_score_gemma":0.00021891,"domain_scores_codex":[0.9987086,0.0003095302,0.000323338,0.0003138162,0.0001777534,0.0001669637],"domain_scores_gemma":[0.9991251,0.0004691169,0.0001403365,0.000133927,0.00004606246,0.00008550427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01215561,0.0005591316,0.008017076,0.00002290274,0.000010365,0.0002572204,0.0005549333,0.0001251513,0.8771866,0.000006477526,0.00002143933,0.1010831],"study_design_scores_gemma":[0.004579103,0.02582061,0.1339727,0.00003740609,0.00005361989,0.0004527202,0.001064609,0.00012893,0.8149199,0.00009604124,0.01874829,0.0001260712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954214,0.0004994224,0.000005081438,0.002851232,0.0004970424,0.0006405575,0.000008796544,0.00002626921,0.00005016605],"genre_scores_gemma":[0.9989585,0.00007477455,0.0001684438,0.0003339416,0.00003813877,0.0004051507,0.000002680054,0.00001287489,0.000005512264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1259556,"threshold_uncertainty_score":0.4115054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428703735757217,"score_gpt":0.3025691662868431,"score_spread":0.288282128929271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}