{"id":"W4281476553","doi":"10.3390/cells11111741","title":"Cell–Cell Contact Mediates Gene Expression and Fate Choice of Human Neural Stem/Progenitor Cells","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; University of Toronto; McGill University; University Health Network","funders":"Canadian Institutes of Health Research; Krembil Foundation","keywords":"Cell biology; Biology; Wnt signaling pathway; Neural stem cell; Progenitor cell; Stem cell; Induced pluripotent stem cell; Cell fate determination; Cellular differentiation; Hippo signaling pathway; Transplantation; Transcription factor; Signal transduction; Embryonic stem cell; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002405254,0.0002135533,0.0002417188,0.0000766646,0.0002145646,0.00002528785,0.0004209021,0.0001066605,0.0001542682],"category_scores_gemma":[0.000004690549,0.000210586,0.0001060819,0.00009625645,0.00007580806,0.000006145167,0.0007473166,0.0002112938,0.00001446627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000218997,"about_ca_system_score_gemma":0.00004932114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005837668,"about_ca_topic_score_gemma":0.000003753154,"domain_scores_codex":[0.9981895,0.0002276902,0.000311736,0.0005100754,0.0003679973,0.0003929909],"domain_scores_gemma":[0.9990773,0.00004689129,0.0001771358,0.0004542916,0.00006915163,0.000175235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005867185,0.0001553825,0.001666993,0.0001264879,0.00001472325,0.00001354188,0.00007892236,0.0001159759,0.9939932,4.512111e-7,0.003690658,0.00008495028],"study_design_scores_gemma":[0.0009893409,0.0005652123,0.0002362923,0.000005358515,0.00001804177,0.00000346865,0.0001610463,0.00009078997,0.9903092,0.000002880809,0.007401232,0.000217077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952766,0.003207106,0.00001644816,0.00001954574,0.0002739,0.0003940649,0.0001384615,0.00001226641,0.000661572],"genre_scores_gemma":[0.9953061,0.0002136549,0.0001283161,0.0000552069,0.0001530324,0.00004019356,0.0001357771,0.00004358693,0.003924124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003710574,"threshold_uncertainty_score":0.8587449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646225611518855,"score_gpt":0.2612018063762551,"score_spread":0.2447395502610665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}