{"id":"W4281476553","doi":"10.3390/cells11111741","title":"Cell–Cell Contact Mediates Gene Expression and Fate Choice of Human Neural Stem/Progenitor Cells","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; University of Toronto; McGill University; University Health Network","funders":"Canadian Institutes of Health Research; Krembil Foundation","keywords":"Cell biology; Biology; Wnt signaling pathway; Neural stem cell; Progenitor cell; Stem cell; Induced pluripotent stem cell; Cell fate determination; Cellular differentiation; Hippo signaling pathway; Transplantation; Transcription factor; Signal transduction; Embryonic stem cell; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016391,0.00013223,0.0001755473,0.0002511504,0.0002020905,0.0004876231,0.0001083576,0.0001573593,0.001092072],"category_scores_gemma":[0.0002572158,0.0001210798,0.0001500444,0.0001990521,0.0002084484,0.000174116,0.000310177,0.0002182914,0.0004416184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219875,"about_ca_system_score_gemma":0.0002473661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005539424,"about_ca_topic_score_gemma":0.00107209,"domain_scores_codex":[0.9996674,0.00005837951,0.0000277159,0.00008364185,0.000117308,0.00004549594],"domain_scores_gemma":[0.9998988,0.00003166954,0.0000226138,0.00001227683,0.00001879657,0.00001583014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004735976,0.000008856743,0.0008433432,0.00002901125,0.000003531284,0.00004822113,0.00004283276,0.00004568764,0.9968801,0.0001000832,0.00002802112,0.001922913],"study_design_scores_gemma":[0.000004331957,0.00006570416,0.02365162,0.000008715955,0.00001463637,0.0001973586,0.00009850664,0.0008801338,0.9728124,0.00009746146,0.002164119,0.000005035818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910282,0.00159777,0.004442289,0.00003449249,0.00001422239,0.00002808373,0.0004721809,0.00002878937,0.00235391],"genre_scores_gemma":[0.995466,0.0006832618,0.001499418,0.0000222296,0.000005546927,0.00003146015,0.0005961718,0.00001204364,0.001683822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092072,"threshold_uncertainty_score":0.003653347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646225611518855,"score_gpt":0.2612018063762551,"score_spread":0.2447395502610665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}