{"id":"W4281478438","doi":"10.1016/j.apsb.2022.05.023","title":"Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein","year":2022,"lang":"en","type":"article","venue":"Acta Pharmaceutica Sinica B","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China; Natural Science Foundation of Beijing Municipality; Chinese Academy of Meteorological Sciences; Public Health Agency of Canada","keywords":"Ebola virus; Ebolavirus; Virology; In vivo; Viral replication; Pharmacology; In vitro; Drug repositioning; Medicine; Drug; Virus; Chemistry; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000085295,0.0001924257,0.0002248314,0.0002004426,0.0001057374,0.0001241541,0.0001700763,0.0002756994,0.001710381],"category_scores_gemma":[0.0001105268,0.00007379563,0.0001850778,0.00006692802,0.0001108997,0.0001918862,0.000126245,0.0003596249,0.0003473966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008242246,"about_ca_system_score_gemma":0.000108236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002179524,"about_ca_topic_score_gemma":0.0004752233,"domain_scores_codex":[0.9999577,0.00001121652,0.00000312219,0.000009379735,0.000009805347,0.000008856492],"domain_scores_gemma":[0.9999658,0.000007730853,0.000009464626,0.000003512823,0.000006122173,0.000007411999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002203098,0.0001005836,0.0001314887,0.0002551068,0.0000176071,0.0001805009,0.00001934553,0.0001082208,0.9882048,0.0001486864,0.0001309163,0.01048238],"study_design_scores_gemma":[0.0001175743,0.002992397,0.002462425,0.00003564296,0.00004291759,0.0009737221,0.00002259623,0.0007640769,0.9789985,0.00008600196,0.01349142,0.00001267033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600888,0.02603366,0.005582907,0.0004226268,0.0001560812,0.0001594232,0.0002502952,0.0001037628,0.007202286],"genre_scores_gemma":[0.9856333,0.006365571,0.004022476,0.0002114472,0.00003406491,0.00003017681,0.0001509555,0.00001623466,0.00353572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001710381,"threshold_uncertainty_score":0.005721807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574519655295256,"score_gpt":0.353663428106102,"score_spread":0.3279182315531495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}