{"id":"W4281479131","doi":"10.3390/antiox11061046","title":"5-Methyltetrahydrofolate Attenuates Oxidative Stress and Improves Kidney Function in Acute Kidney Injury through Activation of Nrf2 and Antioxidant Defense","year":2022,"lang":"en","type":"article","venue":"Antioxidants","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Manitoba; St. Boniface Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation de l’Hôpital Saint-Boniface","keywords":"Oxidative stress; Kidney; Acute kidney injury; Glutathione; Lipid peroxidation; Antioxidant; Pharmacology; Renal ischemia; Superoxide dismutase; Endocrinology; Internal medicine; Chemistry; Medicine; Biochemistry; Ischemia; Reperfusion injury; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000625889,0.0003223224,0.0006119196,0.0005143886,0.0002572895,0.00003546894,0.0001490684,0.0001377635,0.0001621207],"category_scores_gemma":[0.0006133214,0.000309346,0.00008442924,0.0009077335,0.0003003886,0.000645248,0.0004028465,0.0006775578,0.0000056034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001199615,"about_ca_system_score_gemma":0.0003810006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003856504,"about_ca_topic_score_gemma":0.000003006726,"domain_scores_codex":[0.9972469,0.0002866383,0.0005933729,0.0006732983,0.0006815121,0.0005182431],"domain_scores_gemma":[0.9986042,0.0001276511,0.0002944549,0.0004064353,0.000179364,0.0003879135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002068726,0.0003926126,0.1135951,0.0003075179,0.0003480572,0.00004863625,0.001040784,4.661357e-7,0.8733667,0.0002446754,0.005471048,0.003115684],"study_design_scores_gemma":[0.005882961,0.003147247,0.3469139,0.0005876634,0.000373411,0.0001355671,0.001643583,0.0005374328,0.6350674,0.001367866,0.003797865,0.0005451201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943785,0.0001451381,0.0001868759,0.002049675,0.0001757739,0.0009117634,0.001369072,0.00005941654,0.0007237629],"genre_scores_gemma":[0.9957976,0.0008084792,0.0007430345,0.001715603,0.00005175589,0.0001080979,0.000288796,0.00005573918,0.000430883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2382993,"threshold_uncertainty_score":0.9999359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719599822513895,"score_gpt":0.301060957855465,"score_spread":0.283864959630326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}