{"id":"W4281479131","doi":"10.3390/antiox11061046","title":"5-Methyltetrahydrofolate Attenuates Oxidative Stress and Improves Kidney Function in Acute Kidney Injury through Activation of Nrf2 and Antioxidant Defense","year":2022,"lang":"en","type":"article","venue":"Antioxidants","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Manitoba; St. Boniface Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation de l’Hôpital Saint-Boniface","keywords":"Oxidative stress; Kidney; Acute kidney injury; Glutathione; Lipid peroxidation; Antioxidant; Pharmacology; Renal ischemia; Superoxide dismutase; Endocrinology; Internal medicine; Chemistry; Medicine; Biochemistry; Ischemia; Reperfusion injury; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002250302,0.0003705881,0.000648469,0.0003527659,0.0001685336,0.0001747926,0.0002746782,0.0004752263,0.001200849],"category_scores_gemma":[0.0001396398,0.0001165071,0.0004318317,0.0002021896,0.0001853335,0.0002669404,0.0002030892,0.0006772668,0.0001651388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002345467,"about_ca_system_score_gemma":0.0003500399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008062752,"about_ca_topic_score_gemma":0.002165997,"domain_scores_codex":[0.9998727,0.00003248898,0.00001790062,0.00001883506,0.00002774875,0.00003031927],"domain_scores_gemma":[0.9999036,0.000007123366,0.00003461867,0.000008737091,0.00002067165,0.00002536038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004375661,0.001016251,0.0008521402,0.001033325,0.0001497348,0.0002080196,0.00005560127,0.0002027013,0.961241,0.0002518382,0.0004209019,0.03019269],"study_design_scores_gemma":[0.0008203008,0.01523507,0.02117824,0.0001177554,0.0004671652,0.0008604093,0.0001024203,0.001692854,0.9433736,0.0005045617,0.01561551,0.0000321715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9537627,0.03776673,0.005440495,0.0006817771,0.0001748462,0.00008792742,0.0003349965,0.000224538,0.001526096],"genre_scores_gemma":[0.9818572,0.01169929,0.003392248,0.0002308974,0.00005190118,0.00006960257,0.0003583915,0.0000127892,0.002327693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200849,"threshold_uncertainty_score":0.004017234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719599822513895,"score_gpt":0.301060957855465,"score_spread":0.283864959630326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}