{"id":"W4281481439","doi":"10.1038/s41598-022-12188-3","title":"Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; W. M. Keck Foundation","keywords":"CTCF; H3K4me3; Chromatin immunoprecipitation; Biology; Chromatin; Offspring; Sperm; Histone; Epigenetics; Genetics; Histone H3; Andrology; Enhancer; Gene expression; Gene; Promoter; Pregnancy; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001123678,0.0001988888,0.0001780286,0.0005523312,0.00010695,0.0002341704,0.0001547088,0.0002216627,0.002431849],"category_scores_gemma":[0.0001847137,0.0001879072,0.0002300239,0.0002070827,0.0003725178,0.0001285785,0.0002771983,0.0004245828,0.0001904293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003670897,"about_ca_system_score_gemma":0.0002036164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002510931,"about_ca_topic_score_gemma":0.003333466,"domain_scores_codex":[0.999877,0.00001221827,0.000008656608,0.00003978847,0.00003325424,0.00002901085],"domain_scores_gemma":[0.9997371,0.00003498973,0.0001195437,0.00002817205,0.00002605265,0.00005416815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001498052,0.00001313495,0.00452811,0.00002039157,0.00001575262,0.0001164741,0.00002413648,0.00002718001,0.9936539,0.0000488909,0.00002696487,0.001375139],"study_design_scores_gemma":[0.00001780621,0.000305799,0.2842271,0.000007650004,0.00004873235,0.001004437,0.00009504531,0.000590837,0.7123823,0.0001449312,0.001165806,0.000009521274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929938,0.001225651,0.004347552,0.0001125087,0.00001694246,0.00001588106,0.0005937541,0.0001272132,0.0005667371],"genre_scores_gemma":[0.9957564,0.0007451123,0.00129461,0.00004361702,0.000006319011,0.00002149391,0.0003865553,0.00002674975,0.001719031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002510931,"threshold_uncertainty_score":0.008135319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580428030949934,"score_gpt":0.266622169433695,"score_spread":0.2508178891241957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}