{"id":"W4281489712","doi":"10.1038/s41598-022-12584-9","title":"EF-hand protein, EfhP, specifically binds Ca2+ and mediates Ca2+ regulation of virulence in a human pathogen Pseudomonas aeruginosa","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; University of Oklahoma; Simon Fraser University; West Virginia University; Oklahoma Agricultural Experiment Station; Oklahoma State University","keywords":"Virulence; Pseudomonas aeruginosa; Pyocyanin; Biology; Calcium signaling; Second messenger system; Infectivity; Pathogen; Cell biology; EF hand; Plasma protein binding; Signal transduction; Calcium-binding protein; Binding site; Calcium; Microbiology; Biochemistry; Chemistry; Bacteria; Gene; Genetics; Peptide sequence; Quorum sensing","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007587263,0.0002274607,0.000182388,0.00009370416,0.00014363,0.0001209075,0.0001151079,0.0002744455,0.00102155],"category_scores_gemma":[0.000143238,0.00007768813,0.0001628455,0.00007660502,0.000153485,0.00009209386,0.0001449146,0.000257456,0.0003255957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000168665,"about_ca_system_score_gemma":0.0001016059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004796462,"about_ca_topic_score_gemma":0.0004069616,"domain_scores_codex":[0.9999187,0.00001159406,0.000004857671,0.00001833869,0.0000203164,0.00002624743],"domain_scores_gemma":[0.9999285,0.00002078277,0.00001683369,0.000006818161,0.000009224549,0.00001796949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005321407,0.000009417812,0.0001309213,0.00001043298,0.000001392759,0.00004491047,0.000003202117,0.00001781199,0.9993754,0.0000140947,0.00002514417,0.0003139503],"study_design_scores_gemma":[0.00001827099,0.0002272614,0.01785205,0.000008293807,0.00001189089,0.0009271967,0.00002933067,0.00155481,0.976853,0.0000797684,0.002432774,0.000005434586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970748,0.0006249807,0.001376433,0.0000963353,0.00001309337,0.000009050687,0.0001981014,0.00003194291,0.0005753327],"genre_scores_gemma":[0.9966159,0.0001774117,0.001238764,0.0000934317,0.00001042924,0.000009968776,0.0004425474,0.000009336512,0.001402159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102155,"threshold_uncertainty_score":0.003417492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009227220777033548,"score_gpt":0.2222877961688032,"score_spread":0.2130605753917696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}