{"id":"W4281490014","doi":"10.21203/rs.3.rs-1677547/v1","title":"Over supplementation with vitamin B12 alters microbe-host interactions in the gut leading to accelerated Citrobacter rodentium colonization and pathogenesis in mice","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Children's Hospital of Eastern Ontario; University of Alberta","funders":"Canada Research Chairs; University of Alberta","keywords":"Citrobacter rodentium; Vitamin B12; Biology; Lachnospiraceae; Gut flora; Cyanocobalamin; Colonization; Pathogen; Microbiology; Citrobacter; Immune system; Immunology; Endocrinology; Bacteria; Escherichia coli; Enterobacteriaceae; Biochemistry; Gene; Firmicutes","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003541753,0.0006945226,0.0005824771,0.0009102855,0.0002636128,0.0005864615,0.000414681,0.0008222359,0.001879951],"category_scores_gemma":[0.0002102388,0.0003530789,0.0005037726,0.0003111416,0.0006388854,0.0004662075,0.0003644123,0.001498985,0.0005243612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004583822,"about_ca_system_score_gemma":0.0003994845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001262452,"about_ca_topic_score_gemma":0.001797299,"domain_scores_codex":[0.9994154,0.00009800623,0.00006820654,0.0001580536,0.0001230401,0.0001372813],"domain_scores_gemma":[0.9994503,0.00003553583,0.000184418,0.0000574058,0.0000593465,0.0002129784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002124141,0.0003536478,0.0008241385,0.00009565886,0.00001699964,0.00006489656,0.00004672625,0.00005920778,0.9946884,0.0000503872,0.00007447242,0.001601393],"study_design_scores_gemma":[0.0001702563,0.006788209,0.01544592,0.00005640717,0.00009881091,0.0003263568,0.0002525654,0.001005502,0.9731334,0.0001427907,0.002551537,0.00002812616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925769,0.002145332,0.002142776,0.0003349748,0.00007093977,0.00007137503,0.001225351,0.0002049635,0.001227375],"genre_scores_gemma":[0.9879752,0.001201972,0.003627451,0.0002387569,0.00001964436,0.0001886681,0.0007186502,0.00005963638,0.005970099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001879951,"threshold_uncertainty_score":0.006289065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07168919233460842,"score_gpt":0.4120749912038877,"score_spread":0.3403857988692793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}