{"id":"W4281491015","doi":"10.1126/sciadv.abl5032","title":"Selective endocytosis of Ca <sup>2+</sup> -permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Fondazione Italiana per la Ricerca sul Cancro; Deutsche Forschungsgemeinschaft; Hospital for Sick Children; University of Sussex; Wellcome Trust; Agence Nationale de la Recherche; Brigham and Women's Hospital","keywords":"Endocytic cycle; Long-term potentiation; Synaptic plasticity; AMPA receptor; Neuroscience; Endocytosis; Neurotransmission; Cell biology; Glutamate receptor; Biology; Protein subunit; Chemistry; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207098,0.0002622031,0.0002646221,0.0001235889,0.0001516236,0.0003737076,0.0001648086,0.0001873996,0.0004212816],"category_scores_gemma":[0.0001971482,0.0001337267,0.0001730009,0.00007955791,0.000219052,0.0002181988,0.0003051484,0.0004300409,0.0002403569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004643529,"about_ca_system_score_gemma":0.0001796232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004830995,"about_ca_topic_score_gemma":0.0009677662,"domain_scores_codex":[0.9998864,0.00001275446,0.000009626156,0.00002436639,0.00003636645,0.00003045737],"domain_scores_gemma":[0.9999168,0.0000102888,0.00002914016,0.00001090849,0.00001122243,0.00002171875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001106696,0.00001473629,0.0004419465,0.00001690797,0.000003533413,0.00006194963,0.000009020132,0.00005174546,0.9971823,0.000162784,0.00005221998,0.001892253],"study_design_scores_gemma":[0.0000494876,0.0001870503,0.02954096,0.000009248054,0.000022697,0.0005035307,0.00005045807,0.003872679,0.962751,0.0002830243,0.002720219,0.000009685004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961928,0.001246014,0.001337491,0.00008223046,0.0000178154,0.000007312198,0.00007126015,0.00003840262,0.001006525],"genre_scores_gemma":[0.9965926,0.0008206764,0.001415053,0.00004965767,0.000009666063,0.00001084625,0.00009690315,0.00001262559,0.0009919533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004830995,"threshold_uncertainty_score":0.003369093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0373742492685821,"score_gpt":0.3289697990103032,"score_spread":0.2915955497417211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}