{"id":"W4281492138","doi":"10.1016/j.jpsychires.2022.04.037","title":"Real-world effectiveness of ketamine in treatment-resistant depression: A systematic review & meta-analysis","year":2022,"lang":"en","type":"review","venue":"Journal of Psychiatric Research","topic":"Treatment of Major Depression","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Brain and Cognition Discovery Foundation; University Health Network","funders":"","keywords":"Ketamine; Treatment-resistant depression; Meta-analysis; Depression (economics); Medicine; Randomized controlled trial; Antidepressant; Internal medicine; Major depressive disorder; Generalizability theory; Systematic review; MEDLINE; Anesthesia; Psychology; Hippocampus; Biology; Amygdala","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00923803,0.002361813,0.01875312,0.00325037,0.0006267647,0.003325196,0.001991717,0.002322632,0.003756542],"category_scores_gemma":[0.02591271,0.001600939,0.02901188,0.003994791,0.0009273165,0.002140863,0.001787349,0.002794124,0.0003115756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002320772,"about_ca_system_score_gemma":0.002985718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005584753,"about_ca_topic_score_gemma":0.01788597,"domain_scores_codex":[0.9940215,0.002479605,0.00190475,0.0006940615,0.0006794736,0.0002206477],"domain_scores_gemma":[0.9886479,0.008143334,0.002033455,0.0004310545,0.0005485329,0.0001957282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004362341,0.00005744258,0.002431063,0.3492988,0.6307312,0.00009155953,0.00009961534,0.0003221299,0.0002955292,0.0001063878,0.0004235768,0.01178038],"study_design_scores_gemma":[0.001448374,0.0002735601,0.002834332,0.01482948,0.9792645,0.00006364597,0.00004900411,0.0001019559,0.00008926377,0.0001086664,0.0009129675,0.00002418213],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008103075,0.9901997,0.0005081082,0.0001237099,0.0001862263,0.0003043358,0.0003617005,0.00002799023,0.0001851186],"genre_scores_gemma":[0.2223163,0.7717819,0.002623984,0.001111024,0.0002620406,0.0008143384,0.0006890611,0.00003585957,0.0003656333],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01875312,"threshold_uncertainty_score":0.04885596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3197095135993023,"score_gpt":0.5235473093369251,"score_spread":0.2038377957376227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}