{"id":"W4281550232","doi":"10.1038/s41434-022-00349-y","title":"Curing SMA: Are we there yet?","year":2022,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Canada; Government of Canada; Muscular Dystrophy Association","keywords":"SMA*; SMN1; Spinal muscular atrophy; Motor neuron; Disease; Biology; Natural history; Neuromuscular disease; Neuroscience; Bioinformatics; Intensive care medicine; Medicine; Internal medicine; Spinal cord; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001252667,0.001151884,0.002612911,0.00141625,0.0003415341,0.00178034,0.001361148,0.00233241,0.004949054],"category_scores_gemma":[0.001673438,0.0003128221,0.0006933371,0.001343655,0.0007901987,0.002255746,0.0007996034,0.00390184,0.002719778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006569007,"about_ca_system_score_gemma":0.001140516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000911884,"about_ca_topic_score_gemma":0.002696323,"domain_scores_codex":[0.9997249,0.00006618069,0.00003870947,0.00004577877,0.00008868564,0.00003575482],"domain_scores_gemma":[0.9993472,0.000413007,0.00006001434,0.00001801885,0.0001088009,0.00005305877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001626839,0.0000799308,0.0001139891,0.01616272,0.000123852,0.0001770209,0.00004616815,0.0003238394,0.001109226,0.00396898,0.06089373,0.9168379],"study_design_scores_gemma":[0.0000818324,0.0001196475,0.0003293398,0.007774345,0.0002426957,0.0007229526,0.00006543196,0.00008974913,0.000240544,0.002889434,0.9874206,0.000023346],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002813808,0.998565,0.00007395101,0.0005519679,0.0003684012,0.000002214982,0.000009242011,0.000006065581,0.0003950048],"genre_scores_gemma":[0.0002722984,0.9981132,0.0001784461,0.0006975851,0.0003298159,0.000005160333,0.00001836272,0.000002014852,0.0003832319],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004949054,"threshold_uncertainty_score":0.01655626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2324733042154415,"score_gpt":0.4187599251534376,"score_spread":0.1862866209379961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}