{"id":"W4281550232","doi":"10.1038/s41434-022-00349-y","title":"Curing SMA: Are we there yet?","year":2022,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Canada; Government of Canada; Muscular Dystrophy Association","keywords":"SMA*; SMN1; Spinal muscular atrophy; Motor neuron; Disease; Biology; Natural history; Neuromuscular disease; Neuroscience; Bioinformatics; Intensive care medicine; Medicine; Internal medicine; Spinal cord; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002252817,0.0003781108,0.001268807,0.0001986085,0.0001417377,0.00002325547,0.000353138,0.0001587588,0.004511654],"category_scores_gemma":[0.00001693704,0.0002801789,0.0007564041,0.0003788098,0.00005243592,0.00001286162,0.0001365094,0.0006975074,0.0001545767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008932748,"about_ca_system_score_gemma":0.0004301726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009039652,"about_ca_topic_score_gemma":0.000001631908,"domain_scores_codex":[0.9979245,0.0002537235,0.000329437,0.0005144988,0.0005523723,0.000425438],"domain_scores_gemma":[0.9987506,0.00007780263,0.0001530984,0.0008331434,0.00002906708,0.0001562612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002300596,0.000114978,0.000009042472,0.003298487,0.0003711964,0.0001896986,0.00004410372,2.998787e-7,0.0000107532,0.000008135505,0.001694588,0.9942357],"study_design_scores_gemma":[0.0006797683,0.0002062862,0.000009188257,0.001423337,0.0001864409,0.0001865444,0.00004955955,6.877167e-7,0.0000303479,0.00003115973,0.996962,0.0002347512],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001404901,0.9957928,0.00001005226,0.0002795004,0.0002490132,0.001508281,0.00002510038,0.00007391672,0.001920818],"genre_scores_gemma":[0.000005337828,0.9948886,0.00005920282,0.0002185768,0.0002610912,0.0004026293,0.0001033962,0.000163438,0.003897735],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9952673,"threshold_uncertainty_score":0.999965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2324733042154415,"score_gpt":0.4187599251534376,"score_spread":0.1862866209379961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}