{"id":"W4281552781","doi":"10.1186/s12964-022-00843-1","title":"The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin","year":2022,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Hyacinthe; Université de Sherbrooke; Université de Montréal; Ottawa Fertility Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; University of Texas Southwestern Medical Center","keywords":"Hippo signaling pathway; Amphiregulin; YAP1; Granulosa cell; Cell biology; Biology; Signal transduction; Theca; Luteinizing hormone; Internal medicine; Proximity ligation assay; Endocrinology; Follicular phase; Transcription factor; Receptor; Hormone; Epidermal growth factor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001403849,0.0001229364,0.0001247063,0.00005106203,0.0007464842,0.00003580127,0.0003932323,0.00007381906,0.00002439732],"category_scores_gemma":[0.00006131767,0.0001141106,0.00005100866,0.0001534982,0.00007488811,0.000004605672,0.000311392,0.0002080754,0.000004283903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001987206,"about_ca_system_score_gemma":0.00005439499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005257939,"about_ca_topic_score_gemma":0.000005011438,"domain_scores_codex":[0.9984167,0.0006478403,0.0003172061,0.0002303865,0.0002125795,0.0001752514],"domain_scores_gemma":[0.9988939,0.0001555918,0.0001784543,0.0005942815,0.00009129979,0.00008650115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004358198,0.00007732587,0.00002582769,0.000005515549,0.00001455362,3.040435e-7,0.00103812,0.0002555838,0.9957975,0.000007293067,0.001574253,0.0007678826],"study_design_scores_gemma":[0.0006531359,0.0003103445,0.00001876864,0.000006451626,0.00001818988,0.000002600451,0.002374346,0.0002278566,0.9163586,0.00004136888,0.07983554,0.0001528077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988873,0.009616234,0.0002597638,0.0006680246,0.00005318108,0.0001953396,0.00006193997,0.00001465301,0.0002578392],"genre_scores_gemma":[0.9970421,0.0009206025,0.0002035415,0.0003307183,0.00002450881,0.00005557935,0.000254206,0.00002027688,0.001148451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07943893,"threshold_uncertainty_score":0.5741428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073718253659546,"score_gpt":0.2237023481364136,"score_spread":0.2129651655998182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}