{"id":"W4281552781","doi":"10.1186/s12964-022-00843-1","title":"The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin","year":2022,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Hyacinthe; Université de Sherbrooke; Université de Montréal; Ottawa Fertility Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; University of Texas Southwestern Medical Center","keywords":"Hippo signaling pathway; Amphiregulin; YAP1; Granulosa cell; Cell biology; Biology; Signal transduction; Theca; Luteinizing hormone; Internal medicine; Proximity ligation assay; Endocrinology; Follicular phase; Transcription factor; Receptor; Hormone; Epidermal growth factor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162681,0.0002549948,0.0001675517,0.0002370896,0.0002005495,0.0002063664,0.0001189,0.0001769158,0.002428403],"category_scores_gemma":[0.00009130974,0.0001539787,0.0002954128,0.00009202556,0.0002524449,0.0001701027,0.0002935928,0.0005580162,0.0004190617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002141778,"about_ca_system_score_gemma":0.0001706108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546767,"about_ca_topic_score_gemma":0.0006915902,"domain_scores_codex":[0.9999088,0.000009227526,0.000008266918,0.00002784243,0.00002005793,0.00002587418],"domain_scores_gemma":[0.9998859,0.00001172539,0.00004512416,0.00001043373,0.00001229266,0.00003441424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001369981,0.000009022706,0.0002791127,0.00003882578,0.000003333207,0.00002924124,0.00001003995,0.00001435836,0.9985366,0.00007292647,0.0000598539,0.000809721],"study_design_scores_gemma":[0.00005289168,0.0002043453,0.045575,0.00001732449,0.0000234628,0.0002475785,0.00007467577,0.0009570652,0.9463232,0.0001030295,0.006414263,0.000007177045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904484,0.001963395,0.003708585,0.0002529082,0.00003756945,0.00004814141,0.001182507,0.0001141785,0.002244337],"genre_scores_gemma":[0.9911035,0.0009005705,0.002542393,0.0001015224,0.0000202269,0.0001135164,0.001513843,0.00004397885,0.003660406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002428403,"threshold_uncertainty_score":0.008123875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073718253659546,"score_gpt":0.2237023481364136,"score_spread":0.2129651655998182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}