{"id":"W4281554314","doi":"10.3390/biomedicines10061235","title":"IRW (Isoleucine–Arginine–Tryptophan) Improves Glucose Tolerance in High Fat Diet Fed C57BL/6 Mice via Activation of Insulin Signaling and AMPK Pathways in Skeletal Muscle","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Egg Farmers of Canada","keywords":"Internal medicine; Endocrinology; Skeletal muscle; GLUT4; Glucose transporter; Insulin; Glucose uptake; Insulin receptor; AMPK; Insulin resistance; Angiotensin II; Glucose homeostasis; Chemistry; AMP-activated protein kinase; White adipose tissue; Protein kinase A; Adipose tissue; Biology; Kinase; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002870278,0.00112471,0.0007373667,0.0009435536,0.000250177,0.0003972248,0.0004293417,0.0005594267,0.001820956],"category_scores_gemma":[0.0001131368,0.0003946202,0.0005456957,0.0003602463,0.0004418893,0.0003915381,0.0002443546,0.001711276,0.0004341994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002834233,"about_ca_system_score_gemma":0.0003579837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117231,"about_ca_topic_score_gemma":0.002118041,"domain_scores_codex":[0.9997506,0.00003475064,0.00002736186,0.00006016099,0.00005713282,0.00007007675],"domain_scores_gemma":[0.9997544,0.000009718727,0.0000821546,0.00001649416,0.00001761574,0.0001196298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003833009,0.001271697,0.000282114,0.000118711,0.00003955981,0.00006521571,0.00002471398,0.00006520967,0.9912301,0.00005249593,0.0001242975,0.002892843],"study_design_scores_gemma":[0.001494332,0.02023609,0.01937115,0.00006099349,0.0002388855,0.0003645996,0.0001431465,0.001275065,0.9537728,0.0001179795,0.002896394,0.00002856691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955324,0.001670748,0.001036273,0.0002264504,0.00009836374,0.00004166385,0.0004508893,0.0001845121,0.0007586586],"genre_scores_gemma":[0.9845592,0.002702346,0.003409184,0.0002998233,0.00005869916,0.0001543435,0.001221621,0.00007554998,0.007519166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001820956,"threshold_uncertainty_score":0.006091714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336019920386368,"score_gpt":0.243647483951553,"score_spread":0.2302872847476894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}