{"id":"W4281555356","doi":"10.1016/j.chom.2022.05.002","title":"Host hepatic metabolism is modulated by gut microbiota-derived sphingolipids","year":2022,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Yale University","keywords":"Sphingolipid; Biology; Gut flora; Bacteroides thetaiotaomicron; Host (biology); Microbiome; Phenotype; Microbiology; Bacteria; Sphingosine; Microbial metabolism; Cell biology; Bacteroides; Biochemistry; Gene; Bioinformatics; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458503,0.0002622751,0.0002573441,0.0002496918,0.000148692,0.0005847249,0.00007192553,0.0001981738,0.001362929],"category_scores_gemma":[0.0001732674,0.0001705493,0.0002055628,0.0001874062,0.0002515837,0.0002603462,0.000350785,0.0002986854,0.0003345081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000312482,"about_ca_system_score_gemma":0.000221814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000704002,"about_ca_topic_score_gemma":0.001265431,"domain_scores_codex":[0.9998907,0.00003257656,0.000005084021,0.00002038348,0.00001558144,0.00003562854],"domain_scores_gemma":[0.9999008,0.00001294784,0.00002796261,0.00001035995,0.00001487533,0.00003289382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003054576,0.0000243535,0.003099561,0.00003915448,0.00002549505,0.000131385,0.00002355585,0.00007033304,0.9898564,0.0001765946,0.00005360645,0.003445065],"study_design_scores_gemma":[0.000144707,0.0007195499,0.2093806,0.00003600981,0.0001052682,0.0005910472,0.0003332576,0.001756068,0.7833103,0.0008969828,0.002696258,0.0000300111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992611,0.003477998,0.001243833,0.0002210736,0.0000276354,0.000008507429,0.000199489,0.00003919509,0.002171245],"genre_scores_gemma":[0.9970676,0.001117253,0.000525235,0.00004510223,0.00001051222,0.00000576806,0.0001269646,0.00001248724,0.001089124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362929,"threshold_uncertainty_score":0.004559398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004710593681124152,"score_gpt":0.2131269156945727,"score_spread":0.2084163220134486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}