{"id":"W4281555356","doi":"10.1016/j.chom.2022.05.002","title":"Host hepatic metabolism is modulated by gut microbiota-derived sphingolipids","year":2022,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Yale University","keywords":"Sphingolipid; Biology; Gut flora; Bacteroides thetaiotaomicron; Host (biology); Microbiome; Phenotype; Microbiology; Bacteria; Sphingosine; Microbial metabolism; Cell biology; Bacteroides; Biochemistry; Gene; Bioinformatics; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002350351,0.0004378408,0.0004267597,0.0001026681,0.0005880503,0.00006566055,0.0006237974,0.0002295368,0.001012171],"category_scores_gemma":[0.00001146944,0.0004859099,0.0002578894,0.0002825951,0.0001242203,0.000007306958,0.0006938187,0.0003931269,0.0001585236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008864732,"about_ca_system_score_gemma":0.000212573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003713203,"about_ca_topic_score_gemma":0.00002017317,"domain_scores_codex":[0.9975047,0.0001801236,0.0004855368,0.0008860145,0.0001529588,0.0007906762],"domain_scores_gemma":[0.9986413,0.00001065849,0.0002328729,0.0008053159,0.00009881641,0.0002110467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006169099,0.0002289452,0.0001929463,0.00006647332,0.00005870117,0.000005225309,0.0003473358,0.000007559685,0.8609061,0.000003101126,0.1380613,0.00006064695],"study_design_scores_gemma":[0.0008817308,0.0001333688,0.001933162,0.000005872282,0.00004511006,0.00003692842,0.0001157583,0.00001345846,0.5957491,0.000003071225,0.4007013,0.0003811811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883109,0.00812063,0.0001156739,0.0006712641,0.0006786141,0.000509382,0.0009211663,0.00005174335,0.0006206768],"genre_scores_gemma":[0.9817107,0.0007128944,0.0005491883,0.006296407,0.0002151012,0.00004431771,0.001562592,0.0001149633,0.008793861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.265157,"threshold_uncertainty_score":0.9999011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004710593681124152,"score_gpt":0.2131269156945727,"score_spread":0.2084163220134486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}