{"id":"W4281556284","doi":"10.1101/2022.05.24.493347","title":"Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stanford Maternal and Child Health Research Institute; Stanford Bio-X; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Bill and Melinda Gates Foundation; National Defense Science and Engineering Graduate; U.S. Department of Defense; National Institutes of Health; National Science Foundation","keywords":"Pharmacokinetics; Antibody; Drug delivery; Self-healing hydrogels; Drug; Pharmacology; Depot; Immunization; Chemistry; Medicine; Nanotechnology; Materials science; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001139633,0.0002355101,0.0001142317,0.0001198168,0.00006926416,0.0001454746,0.00009865598,0.0001938363,0.001062673],"category_scores_gemma":[0.00006913482,0.00007003627,0.0001788101,0.00007859467,0.0001223681,0.0001931003,0.0001086471,0.0003133953,0.0002532332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001625718,"about_ca_system_score_gemma":0.0001586908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002518837,"about_ca_topic_score_gemma":0.0003648862,"domain_scores_codex":[0.9999564,0.000004497904,0.000002574884,0.00001393179,0.00001238309,0.00001023658],"domain_scores_gemma":[0.9999583,0.000009895753,0.00001483176,0.000004871155,0.000002748696,0.00000942913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003671214,0.00002224138,0.0000628862,0.00001747896,0.000002626175,0.00002535783,0.000005141766,0.0001305666,0.9978424,0.00006322723,0.00003624603,0.001755023],"study_design_scores_gemma":[0.00001280253,0.0003067708,0.0005924603,0.000002555679,0.000005702522,0.0001073417,0.000005088095,0.001678594,0.9962089,0.00003120175,0.001046262,0.000002253674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741965,0.0009283776,0.02169846,0.0001681964,0.00007532544,0.00008499312,0.000299234,0.0001655992,0.002383232],"genre_scores_gemma":[0.9819359,0.0004488546,0.01343437,0.00008737233,0.00002524592,0.00004747407,0.0001726756,0.00003495341,0.003813145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001062673,"threshold_uncertainty_score":0.00355494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02309104328948697,"score_gpt":0.2856339096197822,"score_spread":0.2625428663302952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}