{"id":"W4281556756","doi":"10.1016/j.ymthe.2022.05.023","title":"Serum extracellular vesicles for delivery of CRISPR-CAS9 ribonucleoproteins to modify the dystrophin gene","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Ribonucleoprotein; CRISPR; Duchenne muscular dystrophy; Biology; Cas9; Dystrophin; Guide RNA; Cell biology; Exon; Microvesicles; Molecular biology; Exosome; Intron; Gene; RNA; Genetics; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004755038,0.0002733075,0.0002286887,0.00007287514,0.0003346463,0.0000308429,0.0008597552,0.00009348359,0.00007152903],"category_scores_gemma":[0.00004342961,0.0002474567,0.0003491809,0.0002100232,0.000110186,0.000004812057,0.0003378619,0.000156541,0.00000707982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000361224,"about_ca_system_score_gemma":0.0001140774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002758656,"about_ca_topic_score_gemma":0.000003305783,"domain_scores_codex":[0.9980091,0.000253412,0.0003724337,0.0005571283,0.0003844496,0.0004234285],"domain_scores_gemma":[0.9984723,0.00002202326,0.0001595061,0.001075274,0.0001300717,0.0001408543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006328562,0.0002440151,0.00009495309,0.00001578968,0.0001565591,0.00003100756,0.0001170353,0.004264174,0.9837251,0.0005431426,0.0007336855,0.009441657],"study_design_scores_gemma":[0.001100003,0.0008687844,0.0002329815,0.000004227329,0.00003156523,0.0000177121,0.00012872,0.0003526732,0.9283177,0.0007127196,0.06794498,0.0002879619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9349383,0.01226402,0.04990797,0.0009774214,0.0001463065,0.001402521,0.0002930729,0.00002330913,0.00004705022],"genre_scores_gemma":[0.9931901,0.0001182134,0.004126471,0.001224394,0.0001255639,0.0005694454,0.0001264103,0.00009956138,0.0004199145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06721129,"threshold_uncertainty_score":0.9999978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324249300770155,"score_gpt":0.2479861715702504,"score_spread":0.2347436785625489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}