{"id":"W4281556756","doi":"10.1016/j.ymthe.2022.05.023","title":"Serum extracellular vesicles for delivery of CRISPR-CAS9 ribonucleoproteins to modify the dystrophin gene","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Ribonucleoprotein; CRISPR; Duchenne muscular dystrophy; Biology; Cas9; Dystrophin; Guide RNA; Cell biology; Exon; Microvesicles; Molecular biology; Exosome; Intron; Gene; RNA; Genetics; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003077416,0.0002677403,0.0002270702,0.000211292,0.000200431,0.0006758934,0.0002384558,0.0006635193,0.0009316169],"category_scores_gemma":[0.0002862157,0.0001398794,0.0003042183,0.0001334297,0.0002335214,0.0003069344,0.0004724293,0.0005932847,0.0004218348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000723456,"about_ca_system_score_gemma":0.0003676153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009670256,"about_ca_topic_score_gemma":0.001275096,"domain_scores_codex":[0.9997146,0.00004957845,0.00002547756,0.00005254276,0.0001042381,0.00005354306],"domain_scores_gemma":[0.9999229,0.00001932418,0.00002177708,0.000007791843,0.00001558942,0.00001252715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004580056,0.000009274357,0.00006135395,0.00004873798,0.000008115858,0.00006181946,0.00002590468,0.0002455059,0.9955445,0.000889602,0.000128708,0.002930713],"study_design_scores_gemma":[0.000006855591,0.00003143824,0.0001876833,0.000005856151,0.000007054509,0.0001166909,0.00001299653,0.0019322,0.9936569,0.00008299747,0.003953594,0.000005659787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8664597,0.005160259,0.1186106,0.0007024205,0.0002811174,0.0002142832,0.0008589943,0.0006490742,0.00706355],"genre_scores_gemma":[0.975616,0.0009066467,0.01752685,0.00009824598,0.000008566914,0.00006818383,0.0004529901,0.00009553962,0.005227034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009670256,"threshold_uncertainty_score":0.005249023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324249300770155,"score_gpt":0.2479861715702504,"score_spread":0.2347436785625489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}