{"id":"W4281560563","doi":"10.1101/gad.349585.122","title":"Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance","year":2022,"lang":"en","type":"article","venue":"Genes & Development","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Research UK Cambridge Institute, University of Cambridge; Biotechnology and Biological Sciences Research Council; Diabetes UK; Medical Research Council Canada; Wellcome Trust; BIRAX; Medical Research Council; Directorate for Biological Sciences; British Council; National Institute for Health and Care Research; NIHR Cambridge Biomedical Research Centre; Oregon Health and Science University; Department of Health and Social Care; Cancer Research UK","keywords":"Biology; Senescence; Phenotype; Cellular senescence; Immune system; Immune surveillance; Cell biology; Genetics; Immunology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491428,0.0001424415,0.0001019194,0.0001725969,0.0001079887,0.0002906509,0.00008736076,0.0001370994,0.001102926],"category_scores_gemma":[0.0001152127,0.00007190777,0.0001454221,0.0000703329,0.0001855283,0.0001927664,0.0001915473,0.0004034888,0.0002975006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000169081,"about_ca_system_score_gemma":0.0001341909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001551709,"about_ca_topic_score_gemma":0.0002169417,"domain_scores_codex":[0.9999042,0.00002259657,0.000007710152,0.00001833573,0.0000216997,0.00002541071],"domain_scores_gemma":[0.9998593,0.00001461256,0.00004459866,0.00002229579,0.00002769633,0.00003145351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006188481,0.00001679699,0.0006246391,0.00002862711,0.000002479109,0.00009051255,0.00002213929,0.00004097731,0.9965351,0.0005518946,0.00004524607,0.00197969],"study_design_scores_gemma":[0.0000171353,0.000440071,0.02752199,0.00001743575,0.00001388575,0.00124714,0.00008193262,0.0008501789,0.9605865,0.0006257788,0.008590283,0.000007567905],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790399,0.004186746,0.01071891,0.0001887609,0.00004702307,0.00002832452,0.0003088703,0.0001717575,0.005309623],"genre_scores_gemma":[0.9956363,0.001060401,0.00140132,0.00005331228,0.00001634315,0.00001306297,0.0001291448,0.000009310608,0.001680716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102926,"threshold_uncertainty_score":0.003689647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229228357997154,"score_gpt":0.2508701865950809,"score_spread":0.2285779030151094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}