{"id":"W4281561568","doi":"10.3390/ijms23115863","title":"Structural and Functional Insights into GID/CTLH E3 Ligase Complexes","year":2022,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Protein subunit; Ubiquitin; DNA ligase; Context (archaeology); Saccharomyces cerevisiae; Computational biology; Biology; Ubiquitin-Protein Ligases; Function (biology); Biochemistry; Genetics; Cell biology; Bioinformatics; Chemistry; Yeast; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003401906,0.0008460125,0.0008799788,0.002095385,0.0002257282,0.0008649353,0.0006829632,0.0008195161,0.001888481],"category_scores_gemma":[0.0003293652,0.000349328,0.0003398753,0.00204554,0.0004607732,0.001257185,0.0006148211,0.001414057,0.002130957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006703121,"about_ca_system_score_gemma":0.000723558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006642416,"about_ca_topic_score_gemma":0.0007401155,"domain_scores_codex":[0.9999075,0.00001000704,0.00001364694,0.00002274353,0.00003298939,0.00001313651],"domain_scores_gemma":[0.9999034,0.00002956777,0.00001753893,0.00000477746,0.00002986986,0.00001481115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001113371,0.00007430387,0.0001912325,0.0179366,0.00006118391,0.0003485079,0.00007972021,0.0007166511,0.01269772,0.009825898,0.02066333,0.9372936],"study_design_scores_gemma":[0.000007146283,0.00005323676,0.0005664109,0.001007046,0.00004933942,0.001003628,0.00003022404,0.0001072739,0.002284238,0.001821638,0.9930556,0.00001410207],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002446723,0.9981153,0.000244777,0.00016838,0.0001181635,0.00000290188,0.00002069102,0.000008151535,0.001077015],"genre_scores_gemma":[0.00103259,0.9977508,0.0002863101,0.0001023273,0.00009622215,0.000003564203,0.00004178797,0.000001693212,0.0006846057],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002095385,"threshold_uncertainty_score":0.006317616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04887030169802788,"score_gpt":0.3256529489812632,"score_spread":0.2767826472832353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}