{"id":"W4281561702","doi":"10.1016/j.phyplu.2022.100300","title":"Shikonin impairs mitochondrial activity to selectively target leukemia cells","year":2022,"lang":"en","type":"article","venue":"Phytomedicine Plus","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Guelph","funders":"","keywords":"Myeloid leukemia; Haematopoiesis; Bone marrow; Reactive oxygen species; Apoptosis; Leukemia; Mitochondrial ROS; Cancer research; Mitochondrion; In vivo; Oxidative phosphorylation; Myeloid; Programmed cell death; Chemistry; Biology; Pharmacology; Stem cell; Cell biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781667,0.0001904557,0.0002250252,0.00008261084,0.0001932053,0.00001231899,0.0002574575,0.00005884838,0.0002230128],"category_scores_gemma":[0.00001713588,0.0001940943,0.00009568428,0.0002633139,0.00003265526,0.000002788893,0.0002663305,0.0002198924,0.00001407513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003492775,"about_ca_system_score_gemma":0.0004468715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001254644,"about_ca_topic_score_gemma":0.0000324557,"domain_scores_codex":[0.9986337,0.00007290331,0.0001476637,0.0004591663,0.0003086201,0.0003779564],"domain_scores_gemma":[0.9993634,0.00001250193,0.00007195378,0.0003200423,0.00004986321,0.0001822035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007528037,0.00004982856,0.00002352738,0.000008375755,0.00006180213,0.000008613435,0.0002554793,0.001373982,0.9822248,0.00002139536,0.01305429,0.002165167],"study_design_scores_gemma":[0.001563432,0.001644092,0.0002177209,0.000004425022,0.00002472223,0.00002062938,0.0001562129,0.0003656898,0.763859,0.0001141462,0.231786,0.0002439417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787424,0.0004159608,0.01547518,0.0007636841,0.002398928,0.0006296007,0.0001508161,0.00004275542,0.001380671],"genre_scores_gemma":[0.9937935,0.00002438347,0.0008675423,0.001924815,0.001210234,0.0002069678,0.00006474236,0.00004018645,0.001867588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2187317,"threshold_uncertainty_score":0.7914937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009595983077285791,"score_gpt":0.2527911365872968,"score_spread":0.2431951535100111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}