{"id":"W4281562580","doi":"10.21203/rs.3.rs-1665748/v1","title":"Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Génome Québec; Compute Canada; McGill University","keywords":"DNA methylation; Sperm; Methylation; Biology; Testicular cancer; Male infertility; Epigenetics; Epigenome; Andrology; Cancer; Oncology; Cancer research; Infertility; Internal medicine; Genetics; Medicine; Gene; Pregnancy; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645869,0.0000994273,0.0002166079,0.0004731339,0.0002106236,0.000206742,0.0001185371,0.00021173,0.00174288],"category_scores_gemma":[0.0005342059,0.0001115187,0.0001157767,0.0005522333,0.0001474233,0.0001193236,0.0001687063,0.0001406082,0.0001162372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002213262,"about_ca_system_score_gemma":0.0001464925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002968476,"about_ca_topic_score_gemma":0.004994402,"domain_scores_codex":[0.9998484,0.00003848514,0.00001234736,0.00004383365,0.00003143792,0.0000254412],"domain_scores_gemma":[0.9998136,0.0000463206,0.00007055622,0.00001126767,0.00002918532,0.00002905242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007058739,0.00003044922,0.978703,0.0000608753,0.00009914717,0.0002072281,0.0001997068,0.00009053904,0.009766972,0.00003100678,0.0001904067,0.009914853],"study_design_scores_gemma":[0.000007513432,0.0002188309,0.9970465,0.00000513288,0.00004277419,0.0005481638,0.0001065285,0.00009392251,0.001558591,0.00002260155,0.0003469482,0.000002563235],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973388,0.001837472,0.0001236099,0.00003497717,0.000005807854,0.000006397303,0.0003783336,0.000008412681,0.0002660285],"genre_scores_gemma":[0.9993104,0.0001859358,0.00008538884,0.00002408659,0.000004505255,0.000004066489,0.0001825291,0.000001125189,0.0002018616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002968476,"threshold_uncertainty_score":0.00590241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804653474088216,"score_gpt":0.3657984518337933,"score_spread":0.3377519170929111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}