{"id":"W4281566731","doi":"10.1016/j.actbio.2022.05.036","title":"Mineralized vectors for gene therapy","year":2022,"lang":"en","type":"review","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Genetic enhancement; Mineralization (soil science); Gene delivery; Nanotechnology; Biocompatibility; Surface modification; Materials science; Biochemical engineering; Gene; Biology; Chemistry; Geology; Biochemistry; Metallurgy; Engineering; Soil science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000653434,0.001222615,0.001320882,0.002557404,0.0002593805,0.001023734,0.00107727,0.001194409,0.003189945],"category_scores_gemma":[0.0004933726,0.0004681486,0.0005097317,0.002242417,0.0008284773,0.00110282,0.0008699052,0.00245782,0.002829329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007806077,"about_ca_system_score_gemma":0.0008696608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00086015,"about_ca_topic_score_gemma":0.001342972,"domain_scores_codex":[0.9997411,0.00003516194,0.00002634239,0.00003697754,0.0001344467,0.00002591641],"domain_scores_gemma":[0.9998758,0.00005706189,0.00002249637,0.000007798086,0.00002500285,0.00001173166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001010304,0.000121504,0.00006256781,0.0100406,0.00007076129,0.000262955,0.0000657086,0.0005425836,0.01896743,0.01271166,0.02701902,0.9300342],"study_design_scores_gemma":[0.00002844187,0.00005978413,0.0001879189,0.0008930729,0.00006029567,0.0008003626,0.00001913456,0.0001282595,0.005113615,0.002540684,0.990149,0.0000193977],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001975758,0.9950262,0.001839937,0.0001901497,0.0005790006,0.00001517366,0.00003233227,0.00002835315,0.002091313],"genre_scores_gemma":[0.00146385,0.9928784,0.001733027,0.0001893188,0.0002215652,0.00002922591,0.0000788376,0.000008768183,0.003396945],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003189945,"threshold_uncertainty_score":0.01067144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09441617367813701,"score_gpt":0.3530801167999774,"score_spread":0.2586639431218404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}