{"id":"W4281566731","doi":"10.1016/j.actbio.2022.05.036","title":"Mineralized vectors for gene therapy","year":2022,"lang":"en","type":"review","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Genetic enhancement; Mineralization (soil science); Gene delivery; Nanotechnology; Biocompatibility; Surface modification; Materials science; Biochemical engineering; Gene; Biology; Chemistry; Geology; Biochemistry; Metallurgy; Engineering; Soil science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00015906,0.0004189918,0.0007846498,0.00008613366,0.0001034428,0.00007367223,0.0005407055,0.0003396338,0.0006135157],"category_scores_gemma":[0.00002728597,0.0003405599,0.0005850631,0.00008833261,0.00003830238,0.000002637937,0.0001734061,0.00004442509,0.00002220271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002799029,"about_ca_system_score_gemma":0.0001548334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003497258,"about_ca_topic_score_gemma":0.000002787654,"domain_scores_codex":[0.9984597,0.0001333265,0.0004267348,0.0005634882,0.0001029353,0.0003138228],"domain_scores_gemma":[0.9990615,0.00001405157,0.0002560766,0.0005740677,0.00003236659,0.00006196742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002486344,0.0001015122,9.987632e-7,0.001835309,0.0008280935,0.000006912871,0.00002384183,4.41351e-8,0.5729807,0.000006753051,0.09604158,0.3279256],"study_design_scores_gemma":[0.0003698314,0.000450919,5.414327e-7,0.0001306997,0.0001270275,0.00002689499,0.000003593266,1.610254e-7,0.02777467,0.000005493237,0.9707046,0.0004055332],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008958139,0.9858198,0.00001045127,0.00001318782,0.003392478,0.0008338151,0.0008871917,0.00002520961,0.00005975085],"genre_scores_gemma":[0.0001393586,0.987923,0.00014535,0.0001028824,0.0009994543,0.0007446437,0.008077328,0.00009383146,0.001774154],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8746631,"threshold_uncertainty_score":0.9999046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09441617367813701,"score_gpt":0.3530801167999774,"score_spread":0.2586639431218404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}