{"id":"W4281567617","doi":"10.1016/j.xcrm.2022.100644","title":"Genetic changes associated with relapse in favorable histology Wilms tumor: A Children’s Oncology Group AREN03B2 study","year":2022,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Cancer Moonshot; National Institute of Environmental Health Sciences; Broad Institute; Government of South Australia; Harvard University; St. Baldrick's Foundation; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Wilms' tumor; Loss of heterozygosity; Oncology; Biology; Internal medicine; Gene; Cancer research; Genetics; Medicine; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000530331,0.0003299249,0.0003360545,0.0008456498,0.0007539054,0.0004831617,0.0003875208,0.0004302877,0.001555058],"category_scores_gemma":[0.001319284,0.0001737224,0.0003953808,0.00107196,0.0003914904,0.0001967517,0.0004406997,0.0005404707,0.0002514504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008931273,"about_ca_system_score_gemma":0.0005943524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01281703,"about_ca_topic_score_gemma":0.01157748,"domain_scores_codex":[0.9995157,0.00007929601,0.00003171488,0.0001633091,0.0001182906,0.00009176505],"domain_scores_gemma":[0.9989061,0.0001765756,0.0003038768,0.0001368993,0.0001221241,0.0003543037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000489996,0.0000819446,0.9889367,0.00001201993,0.00007026178,0.002427154,0.0002496805,0.0001402318,0.003568785,0.0001280184,0.0006980578,0.003197221],"study_design_scores_gemma":[0.00003285839,0.0001471636,0.9929826,0.0000104216,0.00004551046,0.004400991,0.0002198021,0.0001541868,0.0006049418,0.0000525036,0.001341237,0.000007650211],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985727,0.00007731234,0.00006304317,0.00007356449,0.000004009322,0.000008515319,0.0005911575,0.000004946072,0.0006045967],"genre_scores_gemma":[0.9983918,0.0001044976,0.0001646195,0.00004995737,0.00000962103,0.0000124565,0.0009490497,0.00001556276,0.0003024168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01281703,"threshold_uncertainty_score":0.02548486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005909087118256114,"score_gpt":0.2186359585039936,"score_spread":0.2127268713857375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}