{"id":"W4281568206","doi":"10.1016/j.cell.2022.05.004","title":"Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity","year":2022,"lang":"en","type":"letter","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Irma T. Hirschl Trust; Instituto de Salud Carlos III; Austrian Science Fund; Innovative Medicines Initiative; Österreichischen Akademie der Wissenschaften","keywords":"Infectivity; Peptidyl-Dipeptidase A; Biology; Cell; Angiotensin-converting enzyme 2; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Renin–angiotensin system; Coronavirus disease 2019 (COVID-19); Molecular biology; Angiotensin II; Enzyme; Receptor; Biochemistry; Virology; Virus; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00217647,0.0005775834,0.0009783021,0.0003411243,0.001910165,0.001924277,0.0011543,0.03296958,0.004567842],"category_scores_gemma":[0.01301643,0.0004087685,0.0008606554,0.0003099316,0.00234604,0.001530802,0.000831756,0.02238177,0.003017381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002617417,"about_ca_system_score_gemma":0.001878328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002413347,"about_ca_topic_score_gemma":0.003223579,"domain_scores_codex":[0.9985583,0.0004409645,0.0001619485,0.000176831,0.0003698344,0.0002921337],"domain_scores_gemma":[0.9932562,0.004919281,0.0003245314,0.0002871662,0.0006729378,0.0005398347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001115227,0.0002293568,0.003905866,0.0002424082,0.0001138167,0.04559591,0.0006309709,0.0002873902,0.006036817,0.01608636,0.9011084,0.02464735],"study_design_scores_gemma":[0.0006245119,0.0004131962,0.006245959,0.0004126648,0.0001392881,0.01382911,0.0009051665,0.001242382,0.002936725,0.02510153,0.9480711,0.00007826364],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.008204868,0.002323263,0.0003029584,0.955708,0.02003594,0.00002781589,0.0001145149,0.00003925458,0.0132433],"genre_scores_gemma":[0.07640112,0.002995541,0.0005999052,0.825349,0.0790453,0.00007969052,0.0001197301,0.00003567435,0.01537401],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03296958,"threshold_uncertainty_score":0.01899081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09806609035264448,"score_gpt":0.3634279376538792,"score_spread":0.2653618473012347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}