{"id":"W4281568206","doi":"10.1016/j.cell.2022.05.004","title":"Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity","year":2022,"lang":"en","type":"letter","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Irma T. Hirschl Trust; Instituto de Salud Carlos III; Austrian Science Fund; Innovative Medicines Initiative; Österreichischen Akademie der Wissenschaften","keywords":"Infectivity; Peptidyl-Dipeptidase A; Biology; Cell; Angiotensin-converting enzyme 2; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Renin–angiotensin system; Coronavirus disease 2019 (COVID-19); Molecular biology; Angiotensin II; Enzyme; Receptor; Biochemistry; Virology; Virus; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001320741,0.0003648707,0.0009609835,0.0002908543,0.0001710171,0.00003775253,0.00059256,0.0005074576,0.00002273492],"category_scores_gemma":[0.0003010576,0.00029888,0.0003757437,0.000460886,0.0005019654,0.0001208157,0.0006253701,0.001745623,0.000003547063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002575811,"about_ca_system_score_gemma":0.0007582384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001718686,"about_ca_topic_score_gemma":0.0004171353,"domain_scores_codex":[0.9968646,0.0004047556,0.000625774,0.0006925027,0.0008533769,0.0005590015],"domain_scores_gemma":[0.9972929,0.0009402142,0.0004469753,0.00109192,0.0002055242,0.00002247089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002321805,0.000327207,0.01024351,0.01169131,0.00005432204,0.0000555947,0.0004809586,6.995617e-7,0.908649,0.000003292464,0.06812261,0.0001392802],"study_design_scores_gemma":[0.001555854,0.0002926338,0.0005653372,0.0003816651,0.0001224134,0.000003119273,0.00004636529,0.00003661741,0.7475208,0.0001055614,0.2491613,0.0002083136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815744,0.001580588,0.00001707269,0.01029772,0.0003978268,0.00214537,0.00007378947,0.00002397232,0.003889282],"genre_scores_gemma":[0.796261,0.00007827782,0.00002321072,0.202278,0.0004213798,0.0001993387,0.00003191377,0.00008184137,0.0006250434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1919802,"threshold_uncertainty_score":0.9999464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09806609035264448,"score_gpt":0.3634279376538792,"score_spread":0.2653618473012347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}