{"id":"W4281569242","doi":"10.1126/science.abl6773","title":"Microglia-mediated degradation of perineuronal nets promotes pain","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université Laval; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Microglia; Perineuronal net; Neuroscience; Spinal cord; Nociception; Neuropathic pain; Peripheral nerve injury; Medicine; Nociceptor; Nerve injury; Central nervous system; Anatomy; Biology; Inflammation; Peripheral nerve; Receptor; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008958646,0.00004185758,0.00006782071,0.00007750753,0.0001711139,0.000005029976,0.00009176908,0.0000061175,0.0002210811],"category_scores_gemma":[0.0002558506,0.0000348802,0.0000188519,0.0003912353,0.00009698935,0.00004491388,0.00005879282,0.00006096288,0.000006405253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004766976,"about_ca_system_score_gemma":0.0001670589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001917562,"about_ca_topic_score_gemma":0.00000122497,"domain_scores_codex":[0.9992308,0.00005230458,0.00008127735,0.0001521692,0.0003590958,0.0001243599],"domain_scores_gemma":[0.9997143,0.0000376764,0.00004051179,0.0001129634,0.00004148785,0.00005305225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002012319,0.0001901527,0.02543433,0.00001065634,0.000004621059,0.00002198971,0.0001421582,0.000004214902,0.9636501,0.0002482406,0.0000821166,0.01019131],"study_design_scores_gemma":[0.002920157,0.004419037,0.3775803,0.00005562249,0.00005757977,0.0001913896,0.000965923,0.02156119,0.5758259,0.001481095,0.01464709,0.0002946512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987559,0.0000545746,0.0001875313,0.0005008093,0.00007799221,0.0001563481,0.000009716104,0.0000177378,0.0002393519],"genre_scores_gemma":[0.997057,0.000002279914,0.002117951,0.0002655418,0.000006304623,0.00001554388,0.00001498567,0.00000334978,0.0005170615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3878242,"threshold_uncertainty_score":0.2420683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597602783110773,"score_gpt":0.2604903297922835,"score_spread":0.2445143019611757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}