{"id":"W4281619380","doi":"10.3390/cells11111787","title":"LINCing Senescence and Nuclear Envelope Changes","year":2022,"lang":"en","type":"review","venue":"Cells","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Qatar National Research Fund","keywords":"Nucleoplasm; Lamin; Senescence; Cell biology; Nuclear lamina; Biology; Cytoplasm; Nuclear protein; DNA repair; Nucleus; Genetics; Transcription factor; DNA; Nucleolus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003372051,0.0008909667,0.001052507,0.002318448,0.0003572709,0.001011735,0.0007233622,0.001221076,0.003162939],"category_scores_gemma":[0.0004988527,0.0002482308,0.0003797887,0.001813798,0.0005133271,0.001256205,0.0007723221,0.001712616,0.002376795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007046813,"about_ca_system_score_gemma":0.000885084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009275714,"about_ca_topic_score_gemma":0.001600148,"domain_scores_codex":[0.9998646,0.00002030375,0.00002026359,0.00002913581,0.00005043539,0.00001532421],"domain_scores_gemma":[0.9998624,0.00005431741,0.00002005668,0.000004801325,0.00003855481,0.00001995021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006830716,0.00005928632,0.0001855836,0.01355263,0.00005370374,0.0003685508,0.00007939078,0.0003136719,0.00263144,0.006271868,0.04181405,0.9346015],"study_design_scores_gemma":[0.000008912311,0.00005200937,0.0006997575,0.001785751,0.00004281799,0.001942444,0.0000392639,0.00005432383,0.0004450126,0.001841881,0.9930734,0.0000144493],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008880229,0.9981723,0.0001116077,0.0002050463,0.0002723421,0.000003523085,0.00001234916,0.00001037211,0.001123636],"genre_scores_gemma":[0.0006199063,0.9979387,0.0001261546,0.0002165772,0.0002062583,0.00000643363,0.00003154548,0.000002024584,0.0008523903],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003162939,"threshold_uncertainty_score":0.01058114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02323362699772162,"score_gpt":0.2543348096119534,"score_spread":0.2311011826142318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}