{"id":"W4281619380","doi":"10.3390/cells11111787","title":"LINCing Senescence and Nuclear Envelope Changes","year":2022,"lang":"en","type":"review","venue":"Cells","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Qatar National Research Fund","keywords":"Nucleoplasm; Lamin; Senescence; Cell biology; Nuclear lamina; Biology; Cytoplasm; Nuclear protein; DNA repair; Nucleus; Genetics; Transcription factor; DNA; Nucleolus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007175715,0.0001718416,0.0002946642,0.00003387232,0.00009651076,0.00002222531,0.0001193101,0.0001828969,0.0002485046],"category_scores_gemma":[0.0000107384,0.0001524686,0.00008121836,0.00005604441,0.00003008536,8.465323e-7,0.0002182824,0.0001527196,0.00002711451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001282811,"about_ca_system_score_gemma":0.00003751391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003650877,"about_ca_topic_score_gemma":0.000002766064,"domain_scores_codex":[0.999324,0.00005005222,0.0001072849,0.0003243746,0.00006387148,0.0001304306],"domain_scores_gemma":[0.9996226,0.000008757028,0.00008692943,0.0002289514,0.000007964866,0.00004474769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003167096,0.000003990936,3.038303e-7,0.001377269,0.00003412794,0.000004822289,0.00002377929,7.920359e-8,0.002676421,0.00001509168,0.002594992,0.9932659],"study_design_scores_gemma":[0.00003604724,0.00007240241,7.202631e-7,0.0001612143,0.0000860244,0.0000396427,0.0000191505,5.139501e-7,0.0001387083,0.000002022165,0.9992689,0.0001745849],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005551419,0.9976537,0.00000673384,0.00000877278,0.0004681843,0.0001486256,0.0000163547,0.00001112514,0.001631014],"genre_scores_gemma":[0.00002100937,0.9981025,0.000165177,0.000140618,0.0003995708,0.000007682115,0.0001095729,0.00004664083,0.00100724],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.996674,"threshold_uncertainty_score":0.6217487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02323362699772162,"score_gpt":0.2543348096119534,"score_spread":0.2311011826142318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}