{"id":"W4281620645","doi":"10.1101/2022.05.28.22275728","title":"Membrane-Localized Mutations Predict the Efficacy of Cancer Immunotherapy","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; University of Chicago","keywords":"Immune system; Immunotherapy; Cancer; Melanoma; Biology; Cancer research; Mutation; Cancer cell; Microsatellite instability; Cancer immunotherapy; Gene; Medicine; Immunology; Genetics; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004539713,0.0002640673,0.0003323523,0.0004743304,0.00009394887,0.0006354334,0.0001458787,0.0003914355,0.00242505],"category_scores_gemma":[0.0008484853,0.00008041754,0.0001771534,0.0002738775,0.0001553928,0.0002415009,0.0001959772,0.0004176616,0.0005436396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002648949,"about_ca_system_score_gemma":0.0001082887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003054645,"about_ca_topic_score_gemma":0.0002913284,"domain_scores_codex":[0.9997395,0.00006449781,0.00002694218,0.00006139136,0.0000779777,0.00002970181],"domain_scores_gemma":[0.9995239,0.000108255,0.0002132368,0.00003421342,0.00006591458,0.00005454045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002886918,0.0003689739,0.4093565,0.000298766,0.000395787,0.0003532819,0.00004726155,0.006406316,0.515379,0.0007261221,0.003230868,0.0605503],"study_design_scores_gemma":[0.00006149256,0.00112664,0.7059113,0.0000744038,0.0003154949,0.002062963,0.0001401983,0.03462555,0.2418179,0.001354535,0.01247154,0.00003793642],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878001,0.004580863,0.003589816,0.000264983,0.00004823104,0.00003230017,0.001175377,0.00009977468,0.00240842],"genre_scores_gemma":[0.9973357,0.0004011064,0.0008427367,0.00005336983,0.00001254715,0.00001194528,0.0006399553,0.000009453498,0.0006929658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00242505,"threshold_uncertainty_score":0.008112609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02470441507619643,"score_gpt":0.3238172468461016,"score_spread":0.2991128317699052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}