{"id":"W4281622178","doi":"10.2174/1381612828666220526125806","title":"Trabectedin in Cancers: Mechanisms and Clinical Applications","year":2022,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National College Students Innovation and Entrepreneurship Training Program; China Postdoctoral Science Foundation; National Natural Science Foundation of China; Harbin Medical University","keywords":"Trabectedin; Ifosfamide; Medicine; Soft tissue sarcoma; Cancer; Ovarian cancer; Sarcoma; Oncology; Cancer research; Pharmacology; Internal medicine; Chemotherapy; Bioinformatics; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004499775,0.0003352455,0.001209615,0.0002109461,0.00009502534,0.00002402647,0.000132544,0.0001521664,0.000801586],"category_scores_gemma":[0.00006065049,0.0002709595,0.0002984547,0.0005086623,0.00009812307,0.00004416022,0.00007422964,0.001081131,0.0000426532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008353193,"about_ca_system_score_gemma":0.001298827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005741638,"about_ca_topic_score_gemma":0.000001298114,"domain_scores_codex":[0.9976526,0.0003775216,0.0007618142,0.0006270561,0.0002560732,0.0003249477],"domain_scores_gemma":[0.9985188,0.0006786255,0.0001479369,0.0002576945,0.00002439844,0.0003725167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002161265,0.0004627907,0.00001225493,0.003832599,0.0002143164,0.00002606921,0.00001854176,5.815772e-7,1.141595e-7,0.0008548865,0.0007681876,0.9937881],"study_design_scores_gemma":[0.001326089,0.0001935078,0.0000118462,0.001941657,0.004936271,0.00005522358,0.00001079014,0.0001882,3.529888e-7,0.0002464702,0.9908612,0.000228326],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[3.324825e-7,0.98239,0.01241209,0.00006720658,0.0005638193,0.003965492,0.00009562836,0.00006532082,0.0004401177],"genre_scores_gemma":[0.00000950888,0.9944217,0.00129115,0.00009801691,0.0002338067,0.003491112,0.0002872391,0.00005116868,0.0001162821],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9935597,"threshold_uncertainty_score":0.9999743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3700288914146371,"score_gpt":0.5688209869214935,"score_spread":0.1987920955068564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}