{"id":"W4281623662","doi":"10.3390/ijms23116160","title":"Prime Editing Permits the Introduction of Specific Mutations in the Gene Responsible for Duchenne Muscular Dystrophy","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Centre Hospitalier Universitaire de Québec","keywords":"Duchenne muscular dystrophy; Exon; Point mutation; Dystrophin; Exon skipping; Molecular biology; Biology; Gene; Genetics; Mutation; Alternative splicing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001266073,0.0000525115,0.00006157223,0.0001169762,0.0001113457,0.00003106745,0.0006001341,0.00001453847,0.00001010885],"category_scores_gemma":[0.0001707226,0.00003599809,0.00009828668,0.000170337,0.00009554104,0.000007670587,0.00006796234,0.0000916251,1.195569e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001871671,"about_ca_system_score_gemma":0.00009628475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004128531,"about_ca_topic_score_gemma":0.000002198136,"domain_scores_codex":[0.9990313,0.00009677652,0.0002425684,0.0001118371,0.0004282467,0.00008927477],"domain_scores_gemma":[0.9994879,0.00003554258,0.0001636218,0.0001010644,0.0001989177,0.00001292871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004328258,0.00003661019,0.0000989227,0.00000146645,0.00002993849,0.00000849823,0.0002855562,0.08241113,0.9145418,0.0006840171,0.0002922681,0.001566486],"study_design_scores_gemma":[0.0006310306,0.0006440553,0.002560458,0.000008449958,0.00002244077,0.0005952653,0.003277373,0.001152299,0.9495307,0.0009137626,0.04056081,0.0001034159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96078,0.00136652,0.03303219,0.003987096,0.0006787927,0.0001049417,0.00001067974,8.782249e-7,0.00003885701],"genre_scores_gemma":[0.9957405,0.00004190031,0.003506042,0.00008235187,0.0005888776,0.00001213787,0.00001022421,0.000004275493,0.00001367494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08125883,"threshold_uncertainty_score":0.146796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106526513810114,"score_gpt":0.3053127387184403,"score_spread":0.2942474735803391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}