{"id":"W4281625351","doi":"10.3390/biom12050641","title":"Insights into a Cancer-Target Demethylase: Substrate Prediction through Systematic Specificity Analysis for KDM3A","year":2022,"lang":"en","type":"article","venue":"Biomolecules","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Demethylase; Demethylation; Biology; Histone; Histone H3; Interactome; Biochemistry; Epigenetics; Computational biology; Gene; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006312194,0.0005483655,0.0004233846,0.0004688053,0.0001960385,0.0004971569,0.0003198802,0.0003453258,0.0007910765],"category_scores_gemma":[0.0009445912,0.000203902,0.0004388501,0.0004386515,0.0001465919,0.0002362554,0.0003085725,0.0005025582,0.0005577987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003416369,"about_ca_system_score_gemma":0.0003966478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000696835,"about_ca_topic_score_gemma":0.001481018,"domain_scores_codex":[0.9997806,0.00005217293,0.00001785519,0.00006730515,0.00006083564,0.00002126537],"domain_scores_gemma":[0.9997273,0.0001038831,0.00006573801,0.0000286087,0.0000401272,0.00003426796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001816678,0.00005252048,0.003029052,0.000122991,0.00003709118,0.0001416604,0.00002740425,0.003217604,0.9788903,0.0002630187,0.00009300484,0.01394366],"study_design_scores_gemma":[0.00001721271,0.0002080165,0.004129841,0.000009246132,0.00004490566,0.0004635673,0.0000273339,0.03254735,0.9601727,0.00026508,0.002094332,0.00002052747],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8586576,0.002285396,0.1349276,0.0001826724,0.00001198911,0.0001689879,0.001646499,0.0007035658,0.001415725],"genre_scores_gemma":[0.8903235,0.0008416965,0.1059011,0.00005278599,0.000005389143,0.00005126396,0.002111032,0.00007229881,0.0006409453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007910765,"threshold_uncertainty_score":0.003338218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075309127392575,"score_gpt":0.2810843588089046,"score_spread":0.2603312675349789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}