{"id":"W4281625351","doi":"10.3390/biom12050641","title":"Insights into a Cancer-Target Demethylase: Substrate Prediction through Systematic Specificity Analysis for KDM3A","year":2022,"lang":"en","type":"article","venue":"Biomolecules","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Demethylase; Demethylation; Biology; Histone; Histone H3; Interactome; Biochemistry; Epigenetics; Computational biology; Gene; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002477375,0.0001855306,0.0002843591,0.0001295375,0.0003598825,0.00003919518,0.0002134379,0.00009373479,0.00003257244],"category_scores_gemma":[0.0000623409,0.0001805724,0.0002578266,0.0005226972,0.00006086056,0.000005830241,0.0001057385,0.0000665129,0.000001811212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006526993,"about_ca_system_score_gemma":0.00007991933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001648602,"about_ca_topic_score_gemma":0.0003172607,"domain_scores_codex":[0.99845,0.0002172259,0.0003957074,0.0004768489,0.0002506447,0.0002095816],"domain_scores_gemma":[0.9991834,0.00002857622,0.0002195667,0.000375274,0.000130177,0.000062976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009692381,0.0001272334,0.003977595,0.0007281876,0.0008643505,0.000002853857,0.0002961311,0.01297291,0.9799479,0.0007090641,0.0002003746,0.00007650132],"study_design_scores_gemma":[0.0006116541,0.0005563497,0.003561502,0.00004052827,0.0007240815,0.000001195825,0.0005300706,0.006056789,0.975414,0.002634586,0.009477379,0.0003918141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8028926,0.01773206,0.1780136,0.00009777344,0.0002673817,0.0006423307,0.0001808516,0.0000242407,0.0001491438],"genre_scores_gemma":[0.9945149,0.0004402718,0.002998044,0.0000728133,0.0001693866,0.0006940521,0.0009214591,0.00002693119,0.0001621107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1916223,"threshold_uncertainty_score":0.7363527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075309127392575,"score_gpt":0.2810843588089046,"score_spread":0.2603312675349789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}