{"id":"W4281626559","doi":"10.1038/s41598-022-13259-1","title":"Label-free multiplex electrochemical immunosensor for early diagnosis of lysosomal storage disorders","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Krabbe disease; Multiplex; Glutaraldehyde; Chemistry; Lysosomal storage disease; Detection limit; Cysteamine; Enzyme replacement therapy; Glucocerebrosidase; Molecular biology; Chromatography; Biochemistry; Medicine; Enzyme; Biology; Pathology; Bioinformatics; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001269291,0.0002165042,0.000460201,0.0003706783,0.0006254379,0.00007027666,0.0004090857,0.00008134566,0.0007322062],"category_scores_gemma":[0.001774379,0.0002145131,0.0003202602,0.001073404,0.0004399791,0.0001205762,0.0004795065,0.0003706753,0.000006327682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000255638,"about_ca_system_score_gemma":0.0004033971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001871995,"about_ca_topic_score_gemma":0.00003857258,"domain_scores_codex":[0.9959509,0.00009160461,0.0007079709,0.0009571555,0.001576519,0.0007158069],"domain_scores_gemma":[0.9973441,0.0002025695,0.0003302962,0.001555644,0.0003525929,0.0002148145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001088164,0.00279012,0.223989,0.0003409026,0.0002705119,0.0005272611,0.001321825,0.00004268729,0.7227823,0.0001309604,0.04090454,0.005811695],"study_design_scores_gemma":[0.01565541,0.005454037,0.07246175,0.0001651479,0.0005588738,0.001452501,0.002326731,0.002329426,0.5976468,0.02204126,0.2781478,0.001760247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940758,0.0009046235,0.0001485092,0.000760146,0.001550581,0.001788235,0.00004185601,0.00008849606,0.000641731],"genre_scores_gemma":[0.9931936,0.00001334941,0.001179809,0.0000405379,0.00005819166,0.0009851044,0.0002242731,0.00005656073,0.004248521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2372433,"threshold_uncertainty_score":0.874759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900484101640185,"score_gpt":0.2866937573941143,"score_spread":0.2676889163777124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}