{"id":"W4281626559","doi":"10.1038/s41598-022-13259-1","title":"Label-free multiplex electrochemical immunosensor for early diagnosis of lysosomal storage disorders","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Krabbe disease; Multiplex; Glutaraldehyde; Chemistry; Lysosomal storage disease; Detection limit; Cysteamine; Enzyme replacement therapy; Glucocerebrosidase; Molecular biology; Chromatography; Biochemistry; Medicine; Enzyme; Biology; Pathology; Bioinformatics; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008970124,0.0009583214,0.0006738032,0.0007126293,0.0002195647,0.0005212888,0.0008922682,0.001532439,0.0005302932],"category_scores_gemma":[0.0006678902,0.000527254,0.0003892443,0.0004119728,0.0003064311,0.0006708986,0.0005536959,0.0008924813,0.0003503709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004482756,"about_ca_system_score_gemma":0.0002929938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003269905,"about_ca_topic_score_gemma":0.0007385517,"domain_scores_codex":[0.9988781,0.0001813069,0.00006210661,0.0003150018,0.000493345,0.00007012304],"domain_scores_gemma":[0.9997583,0.00007249552,0.00004550559,0.00001916888,0.00007606643,0.0000284323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001013757,0.000049157,0.0002126548,0.0001204069,0.0000215222,0.00009281249,0.00002776436,0.0002050055,0.9919662,0.0001818715,0.0001670209,0.006854214],"study_design_scores_gemma":[0.00001606896,0.0001770621,0.0007377441,0.00001132906,0.00003543523,0.0002984699,0.00002112571,0.006922356,0.9898897,0.00009681306,0.001768878,0.00002496458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5868462,0.02630656,0.3758551,0.001004048,0.001637083,0.0004144095,0.0009859303,0.001952332,0.004998351],"genre_scores_gemma":[0.7373607,0.006251033,0.2485338,0.0008693904,0.0002015788,0.0003433319,0.0004133586,0.00004441325,0.00598234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532439,"threshold_uncertainty_score":0.004743874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900484101640185,"score_gpt":0.2866937573941143,"score_spread":0.2676889163777124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}