{"id":"W4281628749","doi":"10.1056/nejmoa2204925","title":"Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":463,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Knight Cancer Institute, Oregon Health and Science University; Houston Methodist Research Institute; Massachusetts General Hospital; Houston Methodist Hospital; Takeda Oncology; Winship Cancer Institute; State University of New York Upstate Medical University; Moffitt Cancer Center; Ohio State University; Barbara Ann Karmanos Cancer Institute; Comprehensive Cancer Center, City of Hope; Medical Center, University of Pittsburgh; Syracuse University; University of Pittsburgh; Memorial Sloan-Kettering Cancer Center; University of Washington; Roswell Park Cancer Institute; University of Pennsylvania; Celgene; U.S. Department of Veterans Affairs; Wayne State University; Takeda Pharmaceuticals North America; Emory University; Bristol-Myers Squibb; National Institutes of Health","keywords":"Medicine; Multiple myeloma; Lenalidomide; Transplantation; Melphalan; Hazard ratio; Autologous stem-cell transplantation; Surgery; Internal medicine; Bortezomib; Dexamethasone; Hematopoietic stem cell transplantation; Clinical endpoint; Randomized controlled trial; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008760025,0.0001016485,0.0003332662,0.000288742,0.00006902849,0.000004826917,0.00007186268,0.00002243248,0.0004210029],"category_scores_gemma":[0.0001397283,0.00005997307,0.00003440355,0.0002275812,0.00006689609,0.00005867445,0.00001399957,0.0003806771,6.640968e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006701552,"about_ca_system_score_gemma":0.0001743892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008401515,"about_ca_topic_score_gemma":0.00002635301,"domain_scores_codex":[0.9985684,0.0001458336,0.00036828,0.000112869,0.0006135794,0.0001910614],"domain_scores_gemma":[0.9992976,0.0001353097,0.0001474757,0.00008528371,0.00007914071,0.0002552219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01382034,0.0002366404,0.1876921,0.00005901308,0.00009437541,0.004817662,0.002606184,0.00001064319,0.004429247,0.00005542947,0.003247712,0.7829306],"study_design_scores_gemma":[0.3072765,0.009817421,0.5894858,0.0007267945,0.00008484125,0.01266166,0.0007222563,0.0001827075,0.0007984733,0.0006239361,0.07750122,0.0001183907],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795615,0.005477182,0.0001002452,0.01379672,0.0001713255,0.0002811202,0.00000457294,0.000006451332,0.0006008667],"genre_scores_gemma":[0.9940548,0.004212196,0.0004176487,0.0003481645,0.0005062225,0.000007343799,0.00001464418,0.0000110026,0.0004279808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7828122,"threshold_uncertainty_score":0.4609686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02580289369441924,"score_gpt":0.3233462153975102,"score_spread":0.297543321703091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}