{"id":"W4281628749","doi":"10.1056/nejmoa2204925","title":"Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":463,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Knight Cancer Institute, Oregon Health and Science University; Houston Methodist Research Institute; Massachusetts General Hospital; Houston Methodist Hospital; Takeda Oncology; Winship Cancer Institute; State University of New York Upstate Medical University; Moffitt Cancer Center; Ohio State University; Barbara Ann Karmanos Cancer Institute; Comprehensive Cancer Center, City of Hope; Medical Center, University of Pittsburgh; Syracuse University; University of Pittsburgh; Memorial Sloan-Kettering Cancer Center; University of Washington; Roswell Park Cancer Institute; University of Pennsylvania; Celgene; U.S. Department of Veterans Affairs; Wayne State University; Takeda Pharmaceuticals North America; Emory University; Bristol-Myers Squibb; National Institutes of Health","keywords":"Medicine; Multiple myeloma; Lenalidomide; Transplantation; Melphalan; Hazard ratio; Autologous stem-cell transplantation; Surgery; Internal medicine; Bortezomib; Dexamethasone; Hematopoietic stem cell transplantation; Clinical endpoint; Randomized controlled trial; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001795974,0.0002398389,0.001057382,0.0002659649,0.0001915533,0.0003308039,0.0003729543,0.0005211175,0.001376938],"category_scores_gemma":[0.001665788,0.0001186277,0.0006293131,0.000335643,0.0004547941,0.0003367762,0.0004073447,0.001499913,0.000126171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003227195,"about_ca_system_score_gemma":0.0004336305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003200941,"about_ca_topic_score_gemma":0.0006883459,"domain_scores_codex":[0.9992987,0.0004316255,0.00004895197,0.00007360906,0.00009679281,0.00005024347],"domain_scores_gemma":[0.9989638,0.0004431695,0.00025544,0.0000701676,0.00002965354,0.0002377906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4097535,0.009130907,0.02206905,0.001662512,0.002708692,0.0002256012,0.000210514,0.005599509,0.009003683,0.0008570325,0.002534499,0.5362445],"study_design_scores_gemma":[0.2447985,0.6622783,0.06118771,0.0007525766,0.003096159,0.001911084,0.00008696388,0.007648309,0.005806542,0.002866933,0.009506046,0.00006099272],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779882,0.01963876,0.0007258013,0.0003956563,0.0001564018,0.0001610708,0.00005788809,0.00003033262,0.0008458089],"genre_scores_gemma":[0.9940845,0.003975633,0.0007962764,0.0003804828,0.0001822918,0.0001640751,0.0001301435,0.000004452998,0.0002821203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001795974,"threshold_uncertainty_score":0.009498179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02580289369441924,"score_gpt":0.3233462153975102,"score_spread":0.297543321703091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}