{"id":"W4281629374","doi":"10.1200/jco.2022.40.16_suppl.tps5621","title":"OZM-114: Phase Ib expansion study of CX-5461in patients with solid tumors and <i>BRCA2 </i>and/or <i>PALB2 </i>mutation.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université de Montréal; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Oncology; Prostate cancer; Adverse effect; Toxicity; Incidence (geometry); Cohort; Clinical trial; Cancer; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001378001,0.001455759,0.00133991,0.000579388,0.000403475,0.0008012609,0.0009869341,0.001128008,0.005543462],"category_scores_gemma":[0.0006275597,0.0004706104,0.0009636883,0.0005080129,0.0007543974,0.000764067,0.0005885347,0.002848257,0.001260247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008914779,"about_ca_system_score_gemma":0.001991464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127755,"about_ca_topic_score_gemma":0.002906043,"domain_scores_codex":[0.9996656,0.0001453049,0.00001974026,0.00004411082,0.0000430917,0.00008210752],"domain_scores_gemma":[0.9995688,0.00004969466,0.00009674182,0.00003813152,0.00002955976,0.000217047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4899884,0.1286131,0.02210473,0.0021878,0.001027456,0.000633036,0.0006491773,0.004101298,0.1454412,0.0007031347,0.01025154,0.1942992],"study_design_scores_gemma":[0.3536885,0.6116138,0.02032829,0.00005587339,0.000467865,0.0004908034,0.0001084235,0.0008304918,0.008090666,0.0001523851,0.004145811,0.00002710462],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885707,0.001711901,0.0005670642,0.0004279672,0.00008503055,0.004906328,0.001377783,0.0001770174,0.002176185],"genre_scores_gemma":[0.9857807,0.001942845,0.001885364,0.0005690639,0.0001012426,0.003683802,0.003394501,0.00004051998,0.002601934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005543462,"threshold_uncertainty_score":0.01854473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03788673541297862,"score_gpt":0.4001008888816943,"score_spread":0.3622141534687157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}