{"id":"W4281632263","doi":"10.1038/s41590-022-01199-x","title":"KSHV-encoded ORF45 activates human NLRP1 inflammasome","year":2022,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity; University of Alberta","funders":"National Institute of Dental and Craniofacial Research","keywords":"Inflammasome; Pyrin domain; NLRP1; Proteases; Serine protease; Protease; Cell biology; Open reading frame; Biology; Chemistry; Virology; Receptor; Caspase; Peptide sequence; Genetics; Biochemistry; Gene; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004912,0.0002929148,0.0001677287,0.0001489197,0.0001612465,0.0006253038,0.00009669782,0.000355465,0.002301457],"category_scores_gemma":[0.0002088855,0.0001132333,0.0004848426,0.0001382546,0.0001529429,0.0002743377,0.0003154856,0.000415392,0.0006413296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002945963,"about_ca_system_score_gemma":0.0001823494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003649381,"about_ca_topic_score_gemma":0.0003292001,"domain_scores_codex":[0.9997348,0.00004374007,0.00002187797,0.00005103399,0.00004737758,0.0001010807],"domain_scores_gemma":[0.999892,0.00002623006,0.00001714078,0.00002673124,0.000009815527,0.00002804986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000367089,0.00006972461,0.0006344399,0.00005316057,0.00001648513,0.0001415555,0.00003847072,0.000107764,0.9954957,0.000289356,0.0001903182,0.002595952],"study_design_scores_gemma":[0.00004312333,0.0003960585,0.01190146,0.00001328575,0.0000244143,0.0008132345,0.0001230532,0.001517361,0.9791804,0.0002408261,0.005736397,0.00001046793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932573,0.001188283,0.00213544,0.0001569181,0.000127852,0.00002791313,0.0005837724,0.00008569101,0.002436865],"genre_scores_gemma":[0.9971582,0.000239524,0.000461239,0.00007636847,0.00001300782,0.000006964933,0.0007857741,0.00001147647,0.001247426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002301457,"threshold_uncertainty_score":0.007699132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002984825484153896,"score_gpt":0.2340191871374992,"score_spread":0.2310343616533453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}