{"id":"W4281632263","doi":"10.1038/s41590-022-01199-x","title":"KSHV-encoded ORF45 activates human NLRP1 inflammasome","year":2022,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity; University of Alberta","funders":"National Institute of Dental and Craniofacial Research","keywords":"Inflammasome; Pyrin domain; NLRP1; Proteases; Serine protease; Protease; Cell biology; Open reading frame; Biology; Chemistry; Virology; Receptor; Caspase; Peptide sequence; Genetics; Biochemistry; Gene; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002106352,0.0002495577,0.0002340712,0.000141149,0.0005795747,0.00002043074,0.0006333296,0.0004978271,0.0005359003],"category_scores_gemma":[0.00009293237,0.0002614149,0.0001647985,0.0002195814,0.0001526656,0.000008312926,0.0006626464,0.001132354,0.00003422686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004723256,"about_ca_system_score_gemma":0.00009954082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002235231,"about_ca_topic_score_gemma":0.00001734736,"domain_scores_codex":[0.998412,0.0001925723,0.0002781729,0.0004633936,0.0001708484,0.0004830512],"domain_scores_gemma":[0.9990816,0.00001659571,0.0001439652,0.000639316,0.00008480259,0.00003373056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001886243,0.00008918741,0.001204648,0.000005661365,0.0001949559,0.000009270852,0.0001113949,0.0000504145,0.9907545,0.001223329,0.00498704,0.001181006],"study_design_scores_gemma":[0.001138697,0.000638242,0.006162977,0.000002709058,0.00001764001,0.00004936984,0.0004226876,0.000003215604,0.4531483,0.0004803446,0.5375916,0.0003441983],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862708,0.005603182,0.00001275556,0.0005479159,0.0008032268,0.0002286878,0.00002215316,0.00005246573,0.006458856],"genre_scores_gemma":[0.9945225,0.0001470774,0.00008319015,0.0009315028,0.0001819253,0.0001273731,0.0007087195,0.00004617753,0.00325159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5376062,"threshold_uncertainty_score":0.9999838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002984825484153896,"score_gpt":0.2340191871374992,"score_spread":0.2310343616533453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}