{"id":"W4281632638","doi":"10.1182/blood.2021014698","title":"PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Blood Services; Ontario Institute for Cancer Research","keywords":"Stem cell; Biology; Cell biology; Protein biosynthesis; Haematopoiesis; Hematopoietic stem cell; Transcription factor; Translation (biology); Chromatin; Activator (genetics); Genetics; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001105362,0.0002376543,0.0001600738,0.0001870454,0.00008707624,0.0002379107,0.00009728975,0.0001221852,0.001461155],"category_scores_gemma":[0.00009363458,0.00007259961,0.0001238401,0.0001098745,0.0001694959,0.00008550796,0.0001637464,0.0003129444,0.0003576817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647929,"about_ca_system_score_gemma":0.0002043631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003499942,"about_ca_topic_score_gemma":0.0006070684,"domain_scores_codex":[0.9999415,0.000009846756,0.000003422753,0.0000165019,0.00001438213,0.00001430456],"domain_scores_gemma":[0.9999591,0.000007799352,0.00001147264,0.000005774294,0.000003546173,0.00001232283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002254684,0.00002224243,0.0005371085,0.00003938895,0.000006073531,0.00003456302,0.000009487677,0.0001134709,0.9954592,0.0001017718,0.0001321648,0.003319043],"study_design_scores_gemma":[0.00001565167,0.0003672363,0.01248026,0.000006068145,0.00001416481,0.0002057612,0.00002440123,0.0008364088,0.9818442,0.00009951671,0.004102465,0.000003735322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990733,0.004561869,0.002092544,0.0002593445,0.00003346985,0.00002478933,0.0006007777,0.0002169464,0.001477302],"genre_scores_gemma":[0.9961881,0.0009678917,0.0008000401,0.00008456576,0.000008865109,0.00001478291,0.0005076933,0.00001697085,0.001411075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001461155,"threshold_uncertainty_score":0.004887998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459617358039023,"score_gpt":0.2389955151881241,"score_spread":0.2243993416077338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}