{"id":"W4281634068","doi":"10.3389/fimmu.2022.890522","title":"Understanding the Concept of Pre-Clinical Autoimmunity: Prediction and Prevention of Systemic Lupus Erythematosus: Identifying Risk Factors and Developing Strategies Against Disease Development","year":2022,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Lupus Foundation of America","keywords":"Medicine; Autoimmunity; Disease; Rheumatoid arthritis; Immunology; Autoimmune disease; Systemic lupus erythematosus; Pathogenesis; Arthritis; Diabetes mellitus; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001223459,0.0009653028,0.001645983,0.002224745,0.0002756605,0.001339966,0.0009934215,0.001634689,0.002815468],"category_scores_gemma":[0.001778552,0.000231117,0.0007196297,0.001689607,0.0007873083,0.001838985,0.000803737,0.002878679,0.001459425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008709614,"about_ca_system_score_gemma":0.001915433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223265,"about_ca_topic_score_gemma":0.001721837,"domain_scores_codex":[0.9996223,0.0001027267,0.00005050971,0.00005930936,0.0001318539,0.00003332387],"domain_scores_gemma":[0.9989931,0.0006206533,0.00009527813,0.00002537867,0.0002074028,0.00005815394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007929462,0.00008436458,0.0002508033,0.02662492,0.0001541584,0.0001341102,0.00007894044,0.0003809856,0.0009520374,0.006911802,0.02400983,0.9403387],"study_design_scores_gemma":[0.00002958267,0.0001694734,0.001380521,0.01213152,0.0002253223,0.001063274,0.0001134276,0.0001481587,0.0003183025,0.005603883,0.9787889,0.0000275698],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005003941,0.9986323,0.0001255305,0.0004707847,0.0002375446,0.000004089126,0.000009344888,0.000004928145,0.0004655167],"genre_scores_gemma":[0.0003379156,0.9989558,0.000153471,0.0002210663,0.0001445102,0.000004949522,0.00001336128,7.660967e-7,0.0001680044],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002815468,"threshold_uncertainty_score":0.009418607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1438753917380488,"score_gpt":0.370507953938605,"score_spread":0.2266325622005562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}