{"id":"W4281634068","doi":"10.3389/fimmu.2022.890522","title":"Understanding the Concept of Pre-Clinical Autoimmunity: Prediction and Prevention of Systemic Lupus Erythematosus: Identifying Risk Factors and Developing Strategies Against Disease Development","year":2022,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Lupus Foundation of America","keywords":"Medicine; Autoimmunity; Disease; Rheumatoid arthritis; Immunology; Autoimmune disease; Systemic lupus erythematosus; Pathogenesis; Arthritis; Diabetes mellitus; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002356152,0.0004264771,0.00257392,0.0007808359,0.0002602392,0.00003518968,0.0003488984,0.0003988215,0.00001129265],"category_scores_gemma":[0.0007173359,0.0003065959,0.0002648647,0.0005062852,0.0009035993,0.000146197,0.0005220955,0.00114596,3.212655e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001101371,"about_ca_system_score_gemma":0.002218153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003407078,"about_ca_topic_score_gemma":0.000006454224,"domain_scores_codex":[0.9942269,0.002130403,0.002264564,0.0005313403,0.00046109,0.0003856537],"domain_scores_gemma":[0.9966187,0.001054337,0.001591783,0.000584712,0.00007230533,0.00007811168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"qualitative","study_design_scores_codex":[0.000837511,0.0003129389,0.4871904,0.1532241,0.008983117,0.00007694733,0.03753763,0.00002293608,0.000007307392,0.001540142,0.0003360112,0.309931],"study_design_scores_gemma":[0.01197479,0.001332374,0.02331807,0.3733558,0.007280258,0.01073263,0.48435,0.0004710935,0.00001697082,0.003833812,0.08135264,0.001981497],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07977519,0.9039737,0.01215316,0.000005626576,0.001600622,0.00236884,0.00004904753,0.00003670248,0.00003710604],"genre_scores_gemma":[0.03623522,0.9623327,0.0008501734,0.00000152354,0.00002355149,0.0002077846,0.0001894963,0.00005703979,0.0001025219],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4638723,"threshold_uncertainty_score":0.9999386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1438753917380488,"score_gpt":0.370507953938605,"score_spread":0.2266325622005562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}