{"id":"W4281634293","doi":"10.3390/cells11111816","title":"LSD1 Inhibition Enhances the Immunogenicity of Mesenchymal Stromal Cells by Eliciting a dsRNA Stress Response","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; Cancer Research Society","keywords":"Mesenchymal stem cell; Immunogenicity; Immune system; Biology; Cancer research; Stromal cell; T cell; Context (archaeology); Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007675292,0.0001532118,0.0001478586,0.00005263811,0.0002867568,0.00002539496,0.0003642293,0.00009573525,0.0002238415],"category_scores_gemma":[0.00005415671,0.0001425503,0.0001464528,0.0002044045,0.0001240378,0.000004118154,0.000500801,0.000312421,0.000006884256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000596722,"about_ca_system_score_gemma":0.0001765524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001041645,"about_ca_topic_score_gemma":0.00001123436,"domain_scores_codex":[0.9979871,0.0005798204,0.0002774242,0.0003616129,0.0004419433,0.0003520828],"domain_scores_gemma":[0.9991682,0.00005821662,0.0001666875,0.0004573869,0.0000897152,0.00005978655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008465355,0.00008424489,0.000001638434,0.00001437692,0.00005243117,0.000007636748,0.0001297135,0.0008083537,0.9948694,0.00001011899,0.002597702,0.0005778575],"study_design_scores_gemma":[0.0005064691,0.0005159748,0.00001377493,0.00001142253,0.00001672561,0.00001013449,0.000636805,0.0001387348,0.9890184,0.00002088251,0.008964091,0.0001465184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957838,0.001276117,0.001609418,0.0001318573,0.0001995876,0.0003292173,0.00041895,0.000009944051,0.00024109],"genre_scores_gemma":[0.9985192,0.0001339528,0.00009841894,0.0001123182,0.00007767735,0.00007525116,0.0001306809,0.00002930056,0.000823247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00636639,"threshold_uncertainty_score":0.5813034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005260936639161331,"score_gpt":0.2355338605623132,"score_spread":0.2302729239231519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}