{"id":"W4281640394","doi":"10.1056/nejmoa2203690","title":"Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":2548,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; National Cancer Institute; First Hospital of Jilin University; West China Hospital, Sichuan University; University of California, San Francisco; Kyungpook National University; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Peking Union Medical College; Cleveland Clinic; Samsung; Universitat de Barcelona; Seoul National University Hospital; College of Medicine, Seoul National University; Memorial Sloan-Kettering Cancer Center; Yonsei University; Chinese Academy of Medical Sciences; Tel Aviv University; Seoul National University; Jilin University; Liaoning Cancer Hospital and Institute; Sichuan University; Sun Yat-sen University; Queen Mary University of London; Cleveland Clinic Foundation; University of Ulsan; Institute of Genetics; AstraZeneca; Cancer Research Institute","keywords":"Trastuzumab; Breast cancer; Medicine; Oncology; Internal medicine; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000747692,0.0002147558,0.0005839727,0.0001890448,0.0001638125,0.0002663486,0.0002045753,0.0002100705,0.0007599106],"category_scores_gemma":[0.0008621488,0.00009203891,0.0002300799,0.0002281592,0.0002411502,0.0001728678,0.0001665991,0.0004207446,0.0001033144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005760767,"about_ca_system_score_gemma":0.000468237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005961757,"about_ca_topic_score_gemma":0.001715716,"domain_scores_codex":[0.9997281,0.0001587381,0.00001324057,0.00002972752,0.0000343667,0.00003587277],"domain_scores_gemma":[0.9996969,0.000106405,0.00006995906,0.00001344825,0.00000935901,0.0001039307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4023675,0.01383734,0.1059474,0.0008019426,0.0015152,0.001298188,0.000377433,0.01110436,0.02960875,0.0006578915,0.004353354,0.4281307],"study_design_scores_gemma":[0.2066874,0.4292376,0.3138679,0.0002901442,0.001417515,0.003024501,0.0001801751,0.01158573,0.01267896,0.001505164,0.01947471,0.00005035645],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967477,0.002451623,0.00007839432,0.000116628,0.00002548746,0.00005581088,0.00003704898,0.000006246889,0.0004808939],"genre_scores_gemma":[0.9975859,0.001458957,0.0002088814,0.0001580289,0.00004597697,0.00007262112,0.0001374746,0.000001872658,0.0003303069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007599106,"threshold_uncertainty_score":0.004179776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217942489314834,"score_gpt":0.3451216111915363,"score_spread":0.3233273622600529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}