{"id":"W4281644503","doi":"10.1038/s41590-022-01227-w","title":"Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19","year":2022,"lang":"en","type":"letter","venue":"Nature Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Svenska Läkaresällskapet; Hjärt-Lungfonden; Knut och Alice Wallenbergs Stiftelse; Science for Life Laboratory; Göran Gustafssons Stiftelser; Uppsala Universitet; Vetenskapsrådet; Jeanssons Stiftelser; Helsingin Yliopisto","keywords":"Mannan-binding lectin; Coronavirus disease 2019 (COVID-19); Lectin; Immunology; Virology; 2019-20 coronavirus outbreak; Biology; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003214506,0.0005514789,0.001311174,0.001160257,0.0003753984,0.00001797319,0.00147625,0.002467796,0.002803636],"category_scores_gemma":[0.001749932,0.0006100172,0.0002600989,0.0006337803,0.0005238668,0.00006537346,0.0009799561,0.005223136,0.0002490957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007418891,"about_ca_system_score_gemma":0.0005898449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006753862,"about_ca_topic_score_gemma":0.0004300982,"domain_scores_codex":[0.9951393,0.00170567,0.0009052203,0.001092522,0.0001473604,0.00100994],"domain_scores_gemma":[0.9958618,0.002188167,0.0004322244,0.001342053,0.000122895,0.00005282491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000497073,0.0007499379,0.03219313,0.0008487978,0.0006283699,0.0004516916,0.0007138091,0.00001436478,0.08556006,0.0002775692,0.8765227,0.001542527],"study_design_scores_gemma":[0.001351307,0.0005770823,0.2679303,0.0001598434,0.0001859119,0.0006600982,0.0001449867,0.000002398995,0.002173579,0.0004234198,0.7256995,0.0006915631],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8247309,0.01069769,0.00006558418,0.1521802,0.006266,0.00268264,0.002703754,0.000224746,0.0004485392],"genre_scores_gemma":[0.9115832,0.00004996923,0.0001039561,0.08564313,0.000202353,0.0008910588,0.0009328579,0.00009352752,0.0004999578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2357372,"threshold_uncertainty_score":0.9996351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03609007553309444,"score_gpt":0.3690258300943756,"score_spread":0.3329357545612812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}