{"id":"W4281644503","doi":"10.1038/s41590-022-01227-w","title":"Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19","year":2022,"lang":"en","type":"letter","venue":"Nature Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Svenska Läkaresällskapet; Hjärt-Lungfonden; Knut och Alice Wallenbergs Stiftelse; Science for Life Laboratory; Göran Gustafssons Stiftelser; Uppsala Universitet; Vetenskapsrådet; Jeanssons Stiftelser; Helsingin Yliopisto","keywords":"Mannan-binding lectin; Coronavirus disease 2019 (COVID-19); Lectin; Immunology; Virology; 2019-20 coronavirus outbreak; Biology; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009175923,0.0006058638,0.0006513381,0.0004206464,0.001189397,0.0009494233,0.0004634592,0.009667939,0.004085601],"category_scores_gemma":[0.005866734,0.0003179598,0.0003969841,0.000197139,0.0009559246,0.0007197089,0.0003348246,0.00514959,0.001200996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009473081,"about_ca_system_score_gemma":0.0006823234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001951732,"about_ca_topic_score_gemma":0.002133442,"domain_scores_codex":[0.9993318,0.0002300069,0.00006256603,0.00009240014,0.0001188874,0.0001643055],"domain_scores_gemma":[0.998064,0.001175097,0.0001247857,0.0001000187,0.0002280385,0.0003080269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001982228,0.0005336051,0.04347644,0.0001867184,0.000182202,0.274239,0.0008545343,0.0003482508,0.008815025,0.01435543,0.6216031,0.03342336],"study_design_scores_gemma":[0.002149486,0.001694569,0.09444197,0.0006615332,0.0004119306,0.2584015,0.002107988,0.01097685,0.008214369,0.04843779,0.5721527,0.0003493733],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.09468226,0.002562713,0.001370852,0.8250331,0.03931843,0.00009846553,0.0002804134,0.0001538112,0.03649991],"genre_scores_gemma":[0.5073337,0.002035071,0.001422717,0.3556866,0.09740262,0.0001229762,0.0002146565,0.0001160792,0.03566566],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009667939,"threshold_uncertainty_score":0.0136677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03609007553309444,"score_gpt":0.3690258300943756,"score_spread":0.3329357545612812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}