{"id":"W4281647171","doi":"10.1002/hep.32599","title":"IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH","year":2022,"lang":"en","type":"article","venue":"Hepatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Gilead Sciences","keywords":"Farnesoid X receptor; Medicine; Internal medicine; Cholestasis; Gastroenterology; Chemistry; Nuclear receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007550071,0.0001769213,0.0005012065,0.0002919348,0.000093433,0.000006625743,0.00005614466,0.00006858231,0.0002189979],"category_scores_gemma":[0.0001066631,0.0001411467,0.00001892863,0.0002771072,0.0003200082,0.00008259853,0.0000945138,0.0002822291,0.000006828137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003443487,"about_ca_system_score_gemma":0.0001889938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008327355,"about_ca_topic_score_gemma":0.0001059446,"domain_scores_codex":[0.9986549,0.0002837194,0.0002366698,0.0003762189,0.0001591459,0.0002893254],"domain_scores_gemma":[0.9993418,0.0001892612,0.00009095055,0.0001869058,0.0000485537,0.0001425115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003917166,0.000418896,0.9910129,0.00007416882,0.00006118678,0.0009596646,0.001236181,0.00000182375,0.000002847075,0.0001245945,0.001152243,0.001038316],"study_design_scores_gemma":[0.006549592,0.0004156644,0.9880003,0.00005715523,0.0001391606,0.0003342648,0.0003117969,0.0001459776,0.00001432328,0.0001273992,0.003738171,0.0001662367],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939383,0.004381517,0.000001916984,0.0007787059,0.00005705524,0.0005585476,0.0001837959,0.00002216793,0.00007794268],"genre_scores_gemma":[0.9976153,0.0002251049,0.00009805315,0.001678771,0.000005166813,0.0001392832,0.000064458,0.00001985507,0.000154051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004156412,"threshold_uncertainty_score":0.5755796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008443505498069635,"score_gpt":0.227136335723954,"score_spread":0.2186928302258844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}