{"id":"W4281647171","doi":"10.1002/hep.32599","title":"IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH","year":2022,"lang":"en","type":"article","venue":"Hepatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Gilead Sciences","keywords":"Farnesoid X receptor; Medicine; Internal medicine; Cholestasis; Gastroenterology; Chemistry; Nuclear receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006602675,0.0002917937,0.0004283504,0.0006319279,0.0002538796,0.0003972907,0.000152952,0.0003748065,0.001422377],"category_scores_gemma":[0.001744161,0.0001986958,0.0003936234,0.0004730814,0.000284952,0.0003325136,0.0003561958,0.0005541782,0.0002274884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002507687,"about_ca_system_score_gemma":0.0001228592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004319373,"about_ca_topic_score_gemma":0.0006838741,"domain_scores_codex":[0.9996278,0.0001414525,0.00005921898,0.00006596118,0.0000534705,0.00005196342],"domain_scores_gemma":[0.9984005,0.0003432553,0.0008592499,0.00004832859,0.0001085599,0.0002401957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009785844,0.00005776547,0.9932279,0.00004190693,0.00006273912,0.0002079481,0.00005138909,0.00008898855,0.002181193,0.00001702502,0.00007577785,0.003008742],"study_design_scores_gemma":[0.00002564881,0.0004592772,0.9975979,0.00001096046,0.00004040122,0.0009444592,0.00007597418,0.0002723759,0.0003626334,0.00002543327,0.0001800616,0.000004826241],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975298,0.00141182,0.0001437998,0.00006244227,0.000007534162,0.00002665563,0.0001189155,0.00000918527,0.0006899578],"genre_scores_gemma":[0.9994493,0.0001285818,0.0001296278,0.00003189439,0.0000116666,0.00001352824,0.0001105302,9.63639e-7,0.0001237324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422377,"threshold_uncertainty_score":0.004758298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008443505498069635,"score_gpt":0.227136335723954,"score_spread":0.2186928302258844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}