{"id":"W4281647929","doi":"10.1016/j.omtn.2022.05.026","title":"Mincle-binding DNA aptamer demonstrates therapeutic potential in a model of inflammatory bowel disease","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Cumming School of Medicine, University of Calgary","keywords":"Aptamer; Inflammatory bowel disease; DNA; Computational biology; Inflammatory Bowel Diseases; Disease; Medicine; Biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522579,0.0003827065,0.0003991832,0.0001996701,0.00007781899,0.0001393696,0.0001537668,0.0005705264,0.0008435542],"category_scores_gemma":[0.00009378212,0.0001062539,0.0001955346,0.0001149678,0.0001777939,0.0001518367,0.0001039454,0.0006689312,0.0001619758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524761,"about_ca_system_score_gemma":0.0001310458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001835081,"about_ca_topic_score_gemma":0.0001857154,"domain_scores_codex":[0.9998685,0.00002224827,0.000009057274,0.00004026801,0.00003081937,0.00002904448],"domain_scores_gemma":[0.9999408,0.00001199395,0.00001699324,0.00000635603,0.00000576236,0.00001813837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001893962,0.0000722143,0.00002657513,0.00003260508,0.000003425772,0.00002547055,0.000006517889,0.00008198238,0.9980174,0.00005651594,0.00002759305,0.001460265],"study_design_scores_gemma":[0.00005543731,0.002690767,0.0006597904,0.00000486931,0.00001702968,0.0002563136,0.000006510403,0.001166569,0.9933475,0.00005434499,0.001736232,0.000004582345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812406,0.004031945,0.01122592,0.0004009838,0.0001691699,0.0001018833,0.0002572416,0.0002707535,0.002301604],"genre_scores_gemma":[0.9879922,0.001443835,0.007503999,0.0001823921,0.00003032514,0.00008901706,0.0003038824,0.0000202854,0.002434098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008435542,"threshold_uncertainty_score":0.002821982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008658538890601135,"score_gpt":0.2393717356274197,"score_spread":0.2307131967368186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}