{"id":"W4281647929","doi":"10.1016/j.omtn.2022.05.026","title":"Mincle-binding DNA aptamer demonstrates therapeutic potential in a model of inflammatory bowel disease","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Cumming School of Medicine, University of Calgary","keywords":"Aptamer; Inflammatory bowel disease; DNA; Computational biology; Inflammatory Bowel Diseases; Disease; Medicine; Biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002520421,0.0002535763,0.0002286113,0.000165821,0.0001400108,0.00001790104,0.0003423074,0.0001031241,0.00001339535],"category_scores_gemma":[0.0000112128,0.0002510608,0.0002645843,0.0002046456,0.0001709643,0.000007712092,0.0001924318,0.0001902084,0.000001037005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004281211,"about_ca_system_score_gemma":0.0001095859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007357108,"about_ca_topic_score_gemma":0.0000030596,"domain_scores_codex":[0.9983658,0.0001774584,0.0003576725,0.0004653243,0.000309278,0.0003244871],"domain_scores_gemma":[0.9991888,0.000005355238,0.0001588657,0.0005030317,0.00005300559,0.00009090941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004396184,0.0001873513,0.003307736,0.00001019235,0.0001120696,0.00003623583,0.00004512202,0.004561367,0.9873474,0.000107817,0.00002473611,0.00382033],"study_design_scores_gemma":[0.001017103,0.0003049043,0.00122669,0.00001588603,0.00005068774,0.000010191,0.000179767,0.01436514,0.9804915,0.001115979,0.0007729538,0.0004492506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916362,0.001364669,0.00638874,0.0001576621,0.00003736075,0.0002505866,0.00004202321,0.00003871182,0.00008403252],"genre_scores_gemma":[0.9972324,0.0003303715,0.001613399,0.0005012717,0.00002709634,0.000045352,0.00009257782,0.00005372826,0.000103765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009803774,"threshold_uncertainty_score":0.9999942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008658538890601135,"score_gpt":0.2393717356274197,"score_spread":0.2307131967368186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}