{"id":"W4281648883","doi":"10.1093/neuonc/noac079.297","title":"IMMU-04. Transcriptional analysis reveals distinct microenvironmental subgroups across pediatric nervous system tumors","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Hospital for Sick Children; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Immune system; Medulloblastoma; Tumor microenvironment; Biology; Cell type; Cancer research; Myeloid; Immunotherapy; Transcriptome; Cell; Immunology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006174622,0.0003188976,0.000471896,0.0009511563,0.0004793733,0.0007962575,0.0002968925,0.0003047745,0.001859481],"category_scores_gemma":[0.0007599696,0.0001898975,0.0005149848,0.001569775,0.0002760208,0.0002447307,0.0006932886,0.0004617889,0.0009455236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000467873,"about_ca_system_score_gemma":0.0006435727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001614237,"about_ca_topic_score_gemma":0.002799301,"domain_scores_codex":[0.9992746,0.00008484857,0.00003879323,0.0003097162,0.0001518856,0.0001402234],"domain_scores_gemma":[0.999486,0.0001277797,0.0001760645,0.0000468795,0.00008775877,0.00007540083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001632206,0.0001629889,0.6934228,0.0008874185,0.0003645362,0.0002986434,0.0006639181,0.003915515,0.2268784,0.0008980178,0.009202145,0.06167343],"study_design_scores_gemma":[0.0000490925,0.0004656023,0.9096001,0.0001142383,0.0002987462,0.0009128245,0.000653106,0.0103102,0.0505603,0.0008766851,0.02612124,0.00003786357],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9224016,0.002925964,0.005556139,0.0002286185,0.00003945858,0.0000525056,0.06499696,0.0005991465,0.003199634],"genre_scores_gemma":[0.8907911,0.0009229591,0.01140413,0.0002416751,0.00003307148,0.0002032188,0.09477728,0.0001732589,0.001453287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001859481,"threshold_uncertainty_score":0.006220579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412706050996435,"score_gpt":0.2691264567533607,"score_spread":0.2549993962433963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}